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Cimiside E

Cat. No. M38856

All AbMole products are for research use only, cannot be used for human consumption.

Cimiside E Structure

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Quality Control & Documentation
Biological Activity

Cimiside E (25-Anhydrocimigenol xyloside) possesses apoptotic action on gastric cancer cells, with an IC50 value of 14.58 μM. Cimiside E induces cell cycle arrest at G2/M phase, and mediates apoptosis through the induction of the caspase cascade for both the extrinsic and intrinsic pathways.

Chemical Information
Molecular Weight 602.8
Formula C35H54O8
CAS Number 154822-57-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Lidiya Moon et al. J Ethnopharmacol. Isoimperatorin, cimiside E and 23-O-acetylshengmanol-3-xyloside from Cimicifugae rhizome inhibit TNF-α-induced VCAM-1 expression in human endothelial cells: involvement of PPAR-γ upregulation and PI3K, ERK1/2, and PKC signal pathways

[2] Lian Yu Guo et al. Arch Pharm Res. Cimiside E arrests cell cycle and induces cell apoptosis in gastric cancer cells

[3] Chun Dan et al. Zhongguo Zhong Yao Za Zhi. [Cycloartane triterpenoid of Cimicifuga foetida]

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Keywords: Cimiside E supplier, Caspase, inhibitors, activators

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