M826

Cat. No. M41329

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Quality Control & Documentation

Purity:
COA
MSDS

Product Information

Biological Activity

M826 is a potent, selective and reversible non-peptide caspase-3 inhibitor with an IC50 value of 0.005 μM for enzymatic activity against caspase-3.

Chemical Information

Molecular Weight	575.7
Formula	C28H45N7O6
Storage	Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m²)	0.007	0.025	0.15	0.05	0.02	0.5
K_m factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B K_m
	Animal A K_m

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hossein Tarrahimofrad et al. Sci Rep. Designing a multi-epitope vaccine to provoke the robust immune response against influenza A H7N9

[2] Fei Yu et al. Cell Host Microbe. A Potent Germline-like Human Monoclonal Antibody Targets a pH-Sensitive Epitope on H7N9 Influenza Hemagglutinin

[3] Hong Chen et al. Acta Crystallogr Sect E Struct Rep Online. Poly[(μ(2)-benzene-1,3-dicarboxyl-ato-κ(2)O(1):O(3)){μ(2)-1,2-bis-[(1H-imidazol-1-yl)meth-yl]benzene-κ(2)N(3):N(3')}zinc]

[4] Sylvie Toulmond et al. Br J Pharmacol. Neuroprotective effects of M826, a reversible caspase-3 inhibitor, in the rat malonate model of Huntington's disease

[5] Byung Hee Han et al. J Biol Chem. Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury

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Signaling Pathways

M826

Quality Control & Documentation

Biological Activity

Chemical Information

Conversion of different model animals based on BSA (PMID: 27057123)

References

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