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NQDI-1 is an inhibitor of ASK1(apoptosis signal-regulating kinase 1), attenuates acute ischemic renal injury by modulating oxidative stress and cell death. NQDI-1 at 30 μM almost completely and 50 μM completely prevented ASK1, JNK and p38 phosphorylation. 30 μM NQDI-1 was sufficient to increase bone volume 64% above control (P=0.04), which was comparable to the 82% increase observed in the KO.
| Molecular Weight | 319.31 |
| Formula | C19H13NO4 |
| CAS Number | 175026-96-7 |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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