Free shipping on all orders over $ 500

Wedelolactone

Cat. No. M4574

All AbMole products are for research use only, cannot be used for human consumption.

Wedelolactone Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
1mg USD 30  USD30 In stock
5mg USD 68  USD68 In stock
10mg USD 118  USD118 In stock
20mg USD 178  USD178 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Wedelolactone, a medicinal plant-derived natural compound, is an inhibitor of IKK that is critical for activation of NF-κB by mediating phosphorylation and degradation of IκBα. Wedelolactone is also an inhibitor of caspase-11.

Chemical Information
Molecular Weight 314.04
Formula C16H10O7
CAS Number 524-12-9
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Nai-Jun Miao, et al. Acta Pharmacol Sin . Caspase-11 promotes renal fibrosis by stimulating IL-1β maturation via activating caspase-1

[2] M Kobori, et al. Cell Death Differ. Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex

[3] Guangju Wang, et al. Wedelolactone protects against cisplatin-induced nephrotoxicity in mice via inhibition of organic cation transporter 2

[4] Rong Fan, et al. Wedelolactone alleviates acute pancreatitis and associated lung injury via GPX4 mediated suppression of pyroptosis and ferroptosis

[5] Hao Pan, et al. Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis

[6] Mao-Mao Zhu, et al. Wedelolactone alleviates doxorubicin-induced inflammation and oxidative stress damage of podocytes by IκK/IκB/NF-κB pathway

[7] Min Cheng, et al. Wedelolactone suppresses IL-1β maturation and neutrophil infiltration in Aspergillus fumigatus keratitis

Related Caspase Products
Z-VAD

Z-VAD is a competitive, irreversible pan-caspase inhibitor. Z-VAD inhibits all 10 caspases, except for caspase-2 which is only weakly inhibited. Z-VAD decreases radiation-induced apoptosis.

PEAQX

PEAQX (NVP-AAM077) is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively.

MMPSI 

MMPSI is a potent and selective small molecule caspase 3 and caspase 7 inhibitor with an IC50 of 1.7 μM for human caspase-3.

Ivachtin

Ivachtin (Caspase-3 Inhibitor VII; compound 7a) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor with an IC50 of 23 nM.

VMY-1-103 

VMY-1-103 is an inhibitor for cyclin/Cdk complex, that arrests the cell cycle at G1 phase.

  Catalog
Abmole Inhibitor Catalog




Keywords: Wedelolactone supplier, Caspase, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.