All AbMole products are for research use only, cannot be used for human consumption.
Etomoxir((R)-(+)-Etomoxir) sodium salt is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig. Etomoxir is developed as an inhibitor of the mitochondrial carnitine palmitoyltransferase-1 (CPT-1) located on the outer mitochondrial membrane. (R)-(+)-Etomoxir sodium salt is R-form of Etomoxir sodium salt. Etomoxir, in the liver can act as peroxisomal proliferator, increasing DNA synthesis and liver growth. Etomoxir is an inhibitor of free fatty acid (FFA) oxidation-related key enzyme CPT1. Etomoxir has also been identified as a direct agonist of PPARα.
Etomoxir significantly inhibits the decrease of bone mineral density (BMD) and bone breaking strength in db/db and high fat (HF)-fed mice and suppresses the reduction of BMSCs-differentiated osteoblasts. Etomoxir inhibits the increase of mitochondrial ROS generation in db/db and HF-fed mice and osteoblasts.
J Hepatol. 2022 Nov 9;S0168-8278(22)03285-8.
Hepatocyte-specific Mas activation enhances lipophagy and fatty acid oxidation to protect against acetaminophen-induced hepatotoxicity in mice
Etomoxir sodium salt purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | Pulmonary artery smooth muscle cells |
| Preparation method | The proliferation of vascular smooth muscle cells was induced by 10–30 ng/mL PDGF-BB. It was shown that the proliferation of PASMCs was also stimulated by PDGF-BB at the similar concentration. After digestion, PASMCs were digested and were cultured in DMEM with 15% FBS. When the cells tended to 80–90% confluences, the medium was replaced by DMEM with 0.02% FBS and starved for 24 h. The cells were pretreated with different doses of ETO (3, 10, 30, 100 µM ETO) for 1 h, and then treated with PDGF-BB (10–30 ng/mL). After incubation for indicated times, PAMSCs were collected and tested. |
| Concentrations | 3, 10, 30, 100, and 300 µM |
| Incubation time | 1 h |
| Animal Experiment | |
|---|---|
| Animal models | male C57BLKS/J lar-Leprdb/db mice |
| Formulation | Saline |
| Dosages | 1 mg/kg twice every week |
| Administration | intraperitoneally injected |
| Molecular Weight | 320.74 |
| Formula | C15H18ClNaO4 |
| CAS Number | 828934-41-4 |
| Form | Solid |
| Solubility (25°C) | DMSO 45 mg/mL Water 5 mg/mL |
| Storage | -20°C, protect from light, sealed |
| Related Apoptosis Products |
|---|
| Coenzyme Q0
Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. |
| C6 Ceramide
C6 Ceramide (C6-Cer) is a short-chain, cell-permeable ceramide pathway activator with anticancer activity. C6 Ceramide-mediated miR-29b expression participates in the progression of multiple myeloma through suppressing the proliferation, migration and angiogenesis of endothelial cells by targeting Akt signal pathway. |
| DB2115 tertahydrochloride
DB2115 tertahydrochloride is a potent inhibitor of myeloid master regulator PU.1. DB2115 tertahydrochloride has the potential for researching cancers, including hematologic cancers. |
| 14-3-3η Protein inhibitor 1
14-3-3η Protein inhibitor 1 is a 14-3-3η protein inhibitor with a KD of 35 µM. |
| Deferoxamine
Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
