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Actinomycin D

Cat. No. M4881

All AbMole products are for research use only, cannot be used for human consumption.

Actinomycin D Structure
Synonym:

Actinomycin Aiv; Dactinomycin; Act D; RASP-101

Size Price Availability Quantity
5mg USD 57  USD57 In stock
10mg USD 105  USD105 In stock
50mg USD 380  USD380 In stock
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Quality Control & Documentation
Biological Activity

Actinomycin D is a compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy.

Product Citations
Customer Product Validations & Biological Datas
Source Theranostics (2020 Apr). Figure 5. Actinomycin D (Abmole Bioscience, US)
Method RNA decay assay
Cell Lines MHCC97H and HepG2 cells
Concentrations 5 μg/mL
Incubation Time -
Results We next sought to assess the RNA decay rate in Mettl3-WT and Mettl3-KR cells treated with the transcription inhibitor actinomycin D to block new RNA synthesis. Snail mRNA expression was decreased, and the Snail mRNA half-lives were significantly shortened in SUMO-mutant Mettl3 cells
Chemical Information
Molecular Weight 1255.41
Formula C62H86N12O16
CAS Number 50-76-0
Solubility (25°C) DMSO ≥ 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Heinicke U,et.al. Oncotarget. JNJ-26481585 primes rhabdomyosarcoma cells for chemotherapeutics by engaging the mitochondrial pathway of apoptosis.

[2] Anthony A Cuneo, et al. J Mol Cell Cardiol. Il-19 reduces VSMC activation by regulation of mRNA regulatory factor HuR and reduction of mRNA stability

[3] Elisabetta Bini, et al. RNA. Stability of mRNA in the hyperthermophilic archaeon Sulfolobus solfataricus

[4] S Li, et al. Toxicol Appl Pharmacol. Superinduction of IL-2 gene expression by vomitoxin (deoxynivalenol) involves increased mRNA stability

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Keywords: Actinomycin D, Actinomycin Aiv; Dactinomycin; Act D; RASP-101 supplier, DNA/RNA Synthesis, inhibitors, activators

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