| Cat.No. | Name | Information |
|---|---|---|
| M15058 | Xanthosine 5'-monophosphate sodium salt | Xanthosine 5' -Monophosphate sodium Salt is an intermediate of purine metabolism and a product of rate-limiting step in guanosine production, which is of great significance in the synthesis of DNA, RNA and glycoproteins. |
| M10541 | Methoxyamine HCl | Methoxyamine is an orally bioavailable small molecule inhibitor with potential adjuvant activity. Methoxyamine covalently binds to apurinic/apyrimidinic (AP) DNA damage sites and inhibits base excision repair (BER), which may result in an increase in DNA strand breaks and apoptosis. |
| M9786 | Nimustine hydrochloride | Nimustine hydrochloride (ACNU) is a DNA cross-linking and DNA alkylating agent, which induces DNA replication blocking lesions and DNA double-strand breaks. |
| M9650 | Triazavirin | Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent, works by inhibiting the synthesis of viral RNA and DNA and replication of genomic fragments. |
| M8964 | Thymidine | Thymidine is a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose. |
| M7515 | Brivudine | Brivudine is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication. |
| M6348 | 5-BrdU | 5-BrdU (Bromodeoxyuridine) is a synthetic thymidine analog; used for cell proliferation assays. |
| M5930 | Rifampicin | Rifampin is a DNA-dependent RNA polymerase inhibitor, it is also a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities. |
| M5791 | Mitomycin C | Mitomycin C (Ametycine) is an antineoplastic antibiotic by inhibiting DNA synthesis. Mitomycin C (Ametycine) is a DNA cross-linking agent and induces DNA damaging. Mitomycin C is an ADC Cytotoxin and induces apoptosis. |
| M5680 | Gemcitabine | Gemcitabine (LY-188011; NSC 613327) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis. |
| M5277 | B02 | B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM). |
| M4881 | Actinomycin D | Actinomycin D (Dactinomycin) is an antibiotic found in Streptomyces microsporum with antibacterial and anti-tumor effects. Actinomycin D is an inhibitor of RNA and protein synthesis. Actinomycin D can inhibit the protein synthesis of bacteria, directly bind to the guanine groups of single-stranded or double-stranded DNA in the transcriptional initiation complex, inhibit the activity of DNA-dependent RNA polymerase, and interfere with the transcription process of DNA, thereby inhibiting mRNA synthesis. Actinomycin D inhibits DNA repair with an IC50 value of 0.42 μM. |
| M4879 | Cycloheximide | Cycloheximide (Naramycin A) is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5 nM. Cycloheximide binds to the E-site of the 60S subunit of the ribosome during the protein synthesis process in eukaryotic cells, blocking the ribosome translocation process mediated by eEF2 and preventing the synthesis of new proteins. Cycloheximide suppresses ferroptosis and inhibits autophagy. |
| M3258 | Thioguanine | Thioguanine is a purine antimetabolite widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients. |
| M2293 | CX-5461 | CX-5461 (Pidnarulex) selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116 cells. |
| M2292 | Cytarabine | Cytarabine (Cytosine arabinoside, AraC) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM. |
| M2291 | Azacitidine | Azacitidine is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases. |
| M2290 | Oxaliplatin | Oxaliplatin is a DNA synthesis inhibitor which inhibits DNA synthesis by conforming DNA adducts. |
| M2289 | 5-Fluorouracil | 5-Fluorouracil (5-FU) is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. |
| M2288 | Carboplatin | Carboplatin (NSC 241240) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism. |
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