DNA/RNA Synthesis DNA/RNA Synthesis

Inhibitors

Cat.No.	Name	Information
M4879	Cycloheximide (NSC-185)	Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5 nM.
M2082	Streptozotocin	Streptozotocou (STZ) is a kind of glucosamine - nitrosourea derivative.
M2129	Temozolomide (TMZ)	Temozolomide (TMZ) is an oral DNA methylating, chemotherapeutic agent.
M2223	Cisplatin	Cisplatin is an inorganic platinum complex that inhibits DNA synthesis by forming DNA crosslinking agents, inactivates GPXs, reduces cell GSH and induces iron death in HCT116 and A549 cells.
M2289	5-fluorouracil	5-fluorouracil (5-FU) is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools.
M11341	Tempo	Tempo is a nitric oxide radical and a selective scavenging agent of ROS that disambiguates superoxides in catalytic cycles. Tempo can induce DNA strand breaking and can be used as an organic catalyst for the oxidation of primary alcohols to aldehydes. Tempo has mutagenic and antioxidant effects.
M11056	NSC 617145	NSC 617145 is a selective werner syndrome helicase (WRN) helicase inhibitor,IC50 The value is 230 nM. NSC 617145 inhibit WRN ATPase and induce double-strand rupture (DSB) and chromosomal abnormalities. NSC 617145 is selective to WRN and superior to BLM, FANCJ, ChlR1, RecQ, and UvrD helicases.
M10561	IMP-1088	IMP-1088 is a novel potent and selective blocker of N-myristoylation in cells. IMP-1088 is also a potent human N-myristoyltransferases NMT1 and NMT2 dual inhibitor with IC50s of <1 nM for HsNMT1 and HsNMT2.
M10541	Methoxyamine HCl	Methoxyamine is an orally bioavailable small molecule inhibitor with potential adjuvant activity. Methoxyamine covalently binds to apurinic/apyrimidinic (AP) DNA damage sites and inhibits base excision repair (BER), which may result in an increase in DNA strand breaks and apoptosis.
M10506	RK-33	RK-33 is a first-in-class, potent and selective DDX3 (RNA helicase) inhibitor, it binds to DDX3 and abrogates its activity.
M10362	Beaucage reagent	Beaucage reagent is a potent DNA cleavage agent. Beaucage reagent can be used for preparing phosphorothioate oligomers.
M10128	L189	L189 is a novel human DNA ligase inhibitor with IC50s of 5 μM, 9 μM and 5 μM for hLigI, hLigIII and hLigIV, respectively.
M10080	Saccharin 1-methylimidazole	Saccharin 1-methylimidazole (also known as SMI) is an activator for DNA and RNA synthesis.
M10037	Lurbinectedin	Lurbinectedin, also known as PM01183, is a covalent DNA minor groove binder with potential antineoplastic activity.
M9860	Bleomycin A5 Hydrochloride	Bleomycin A5 Hydrochloride is a unique antibiotic of the bleomycin family that is toxic to eukaryotic and prokaryotic cells.
M9797	1-Methyl-3-nitro-1-nitrosoguanidine (MNNG)	Methylnitronitrosoguanidine (MNNG) is an alkylating agent with toxic and mutagenic effects.
M9786	Nimustine hydrochloride	Nimustine hydrochloride (ACNU) is a DNA cross-linking and DNA alkylating agent, which induces DNA replication blocking lesions and DNA double-strand breaks.
M9650	Triazavirin	Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent, works by inhibiting the synthesis of viral RNA and DNA and replication of genomic fragments.
M9527	BMVC-8C3O	BMVC-8C3O is a DNA G-quadruplexe (G4) ligand which can induce topological conversion of non-parallel to parallel forms in human telomeric DNA G4s.
M9506	TH5487	TH5487 is a selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC50 of 342 nM.
M9270	COH29	COH29 is an orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic activity.
M9262	Plicamycin	Plicamycin, also known as mithramycin or Mithramycin A is a n antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity.
M9214	GC7 Sulfate	GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor.
M9180	Pyridostatin Trifluoroacetate Salt	Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer, with a Kd of 490 nM.
M9118	Chebulinic acid	Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

Signaling Pathways

Product Type

DNA/RNA Synthesis DNA/RNA Synthesis

Get to Know Us

Customer Support

Resources

Contact Us