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Nimustine hydrochloride

Cat. No. M9786
Nimustine hydrochloride Structure
Synonym:

NSC-245,382

Size Price Availability Quantity
5mg USD 55  USD55 In stock
10mg USD 85  USD85 In stock
25mg USD 165  USD165 In stock
50mg USD 260  USD260 In stock
100mg USD 470  USD470 In stock
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Quality Control & Documentation
Biological Activity

Nimustine hydrochloride (ACNU) is a DNA cross-linking and DNA alkylating agent, which induces DNA replication blocking lesions and DNA double-strand breaks. Nimustine hydrochloride inhibits DNA synthesis, it is commonly used in chemotherapy for glioblastomas.

Product Citations
Chemical Information
Molecular Weight 309.15
Formula C9H14Cl2N6O2
CAS Number 55661-38-6
Solubility (25°C) DMSO ≥ 50 mg/mL
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Maja T Tomicic, et al. Oncotarget. Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM

[2] Sandor L Beko, et al. Acta Crystallogr C. Nimustine hydrochloride: the first crystal structure determination of a 2-chloroethyl-N-nitrosourea hydrochloride derivative by X-ray powder diffraction and solid-state NMR

[3] Ryuta Saito, et al. J Neurosurg Pediatr. Regression of recurrent glioblastoma infiltrating the brainstem after convection-enhanced delivery of nimustine hydrochloride

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