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Nimustine hydrochloride (ACNU) is a DNA cross-linking and DNA alkylating agent, which induces DNA replication blocking lesions and DNA double-strand breaks. Nimustine hydrochloride inhibits DNA synthesis, it is commonly used in chemotherapy for glioblastomas.
Oncotarget. 2015 Oct 20;6(32):33755-68.
Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM
Nimustine hydrochloride purchased from AbMole
| Molecular Weight | 309.15 |
| Formula | C9H14Cl2N6O2 |
| CAS Number | 55661-38-6 |
| Solubility (25°C) | DMSO ≥ 50 mg/mL |
| Storage | 2-8°C, protect from light, dry, sealed |
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