All AbMole products are for research use only, cannot be used for human consumption.
Gemcitabine is an antimetabolites, which inhibits DNA synthesis with an IC50 of 0.06 µM. Gemcitabine is a nucleoside analogue that is incorporated into replicating DNA, resulting in partial chain termination and stalling of replication forks.
Cancer Metab. 2025 Feb 10;13(1):7.
FOXO3a/miR-4259-driven LDHA expression as a key mechanism of gemcitabine sensitivity in pancreatic ductal adenocarcinoma
Gemcitabine Hydrochloride purchased from AbMole
Oncol Lett. 2022 May;23(5):163.
AK4P1 is a cancer-promoting pseudogene in pancreatic adenocarcinoma cells whose transcripts can be transmitted by exosomes
Gemcitabine Hydrochloride purchased from AbMole
Int J Oncol. 2020 Jan;56(1):47-68.
Circulating non‑coding RNA‑biomarker potential in neoadjuvant chemotherapy of triple negative breast cancer?
Gemcitabine Hydrochloride purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | BxPC-3, PANC-1 and PaCa-2 cell lines |
| Preparation method | Cell Counts. The cells were plated in 6-well plates. Twenty-four hours later, the cells were treated with vehicle, gemcitabine, DMAPT, or the combination. After 72 h of treatment, trypan blue-excluded cell counts were performed in duplicate using a hemocytometer. Cell growth was expressed relative to vehicle-treated cells (100 %). |
| Concentrations | 0, 0.005, 0.01, 0.02, 0.04 μM |
| Incubation time | 72 h |
| Animal Experiment | |
|---|---|
| Animal models | MIA PaCa-2 Xenografts model in athymic nude mice |
| Formulation | phosphate-buffered saline, PBS |
| Dosages | a single dose of 50 or 100 mg/kg |
| Administration | intraperitoneal injection |
| Molecular Weight | 299.66 |
| Formula | C9H11F2N3O4.HCI |
| CAS Number | 122111-03-9 |
| Solubility (25°C) | Water 30 mg/mL DMSO 50 mg/mL |
| Storage | 2-8°C, protect from light, dry, sealed |
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| Tetrahydrouridine
Tetrahydrouridine (THU) is potent inhibitor of cytidine deaminase (CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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