All AbMole products are for research use only, cannot be used for human consumption.
Gemcitabine is an antimetabolites, which inhibits DNA synthesis with an IC50 of 0.06 µM. Gemcitabine is a nucleoside analogue that is incorporated into replicating DNA, resulting in partial chain termination and stalling of replication forks.
Cancer Metab. 2025 Feb 10;13(1):7.
FOXO3a/miR-4259-driven LDHA expression as a key mechanism of gemcitabine sensitivity in pancreatic ductal adenocarcinoma
Gemcitabine Hydrochloride purchased from AbMole
Oncol Lett. 2022 May;23(5):163.
AK4P1 is a cancer-promoting pseudogene in pancreatic adenocarcinoma cells whose transcripts can be transmitted by exosomes
Gemcitabine Hydrochloride purchased from AbMole
Int J Oncol. 2020 Jan;56(1):47-68.
Circulating non‑coding RNA‑biomarker potential in neoadjuvant chemotherapy of triple negative breast cancer?
Gemcitabine Hydrochloride purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | BxPC-3, PANC-1 and PaCa-2 cell lines |
| Preparation method | Cell Counts. The cells were plated in 6-well plates. Twenty-four hours later, the cells were treated with vehicle, gemcitabine, DMAPT, or the combination. After 72 h of treatment, trypan blue-excluded cell counts were performed in duplicate using a hemocytometer. Cell growth was expressed relative to vehicle-treated cells (100 %). |
| Concentrations | 0, 0.005, 0.01, 0.02, 0.04 μM |
| Incubation time | 72 h |
| Animal Experiment | |
|---|---|
| Animal models | MIA PaCa-2 Xenografts model in athymic nude mice |
| Formulation | phosphate-buffered saline, PBS |
| Dosages | a single dose of 50 or 100 mg/kg |
| Administration | intraperitoneal injection |
| Molecular Weight | 299.66 |
| Formula | C9H11F2N3O4.HCI |
| CAS Number | 122111-03-9 |
| Solubility (25°C) | Water 30 mg/mL DMSO 50 mg/mL |
| Storage | 2-8°C, protect from light, dry, sealed |
| Related DNA/RNA Synthesis Products |
|---|
| Mizoribine
Mizoribine (Bredinin) is an imidazole nucleoside and an immunosuppressive agent with an IC50 of approximately 100 μM. Mizoribine inhibits replication of SARS-CoV with IC50s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively. |
| CDDP
Cisplatin is an inorganic platinum complex that inhibits DNA synthesis by forming DNA crosslinking agents, inactivates GPXs, reduces cell GSH and induces iron death in HCT116 and A549 cells. |
| Raltitrexed
Raltitrexed is an inhibitor of thymidylate synthase used in cancer chemotherapy. |
| Carmofur
Carmofur is a pyrimidine analog that is a prodrug of 5-fluorouracil (5-FU), which inhibits DNA Synthesis and has better antiproliferative activity than 5-FU. Carmofur is an inhibitor of Acidic Ceramidase (ASAH1) and a potential lead compound for non-cancer diseases such as Krabbe disease, acute lung injury (ALI), Parkinson's disease (PD), dementia, etc. Carmofur also has antifungal and antimicrobial properties. |
| 5-Fluorouracil
5-Fluorouracil (5-FU) is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. |
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Products are for research use only. Not for human use. We do not sell to patients.
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