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Carmofur

Cat. No. M2247

All AbMole products are for research use only, cannot be used for human consumption.

Carmofur Structure
Synonym:

HCFU

Size Price Availability Quantity
10mM*1mL in DMSO USD 30  USD30 In stock
50mg USD 37  USD37 In stock
100mg USD 53  USD53 In stock
200mg USD 65  USD65 In stock
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Quality Control & Documentation
Biological Activity

Carmofur is a pyrimidine analog that is a prodrug of 5-fluorouracil (5-FU), which inhibits DNA Synthesis and has better antiproliferative activity than 5-FU. Carmofur is an inhibitor of Acidic Ceramidase (ASAH1) and a potential lead compound for non-cancer diseases such as Krabbe disease, acute lung injury (ALI), Parkinson's disease (PD), dementia, etc. Carmofur also has antifungal and antimicrobial properties. 

Product Citations
Chemical Information
Molecular Weight 257.26
Formula C11H16FN3O3
CAS Number 61422-45-5
Solubility (25°C) DMSO 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Niloofar Hemati, et al. Structural modification of antineoplastic drug carmofur designed to the inhibition of SARS-CoV-2 main protease: A theoretical investigation

[2] Zhenming Jin, et al. Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur

[3] Alexey Dementiev, et al. Molecular Mechanism of Inhibition of Acid Ceramidase by Carmofur

[4] S Matsumoto, et al. Carmofur-induced leukoencephalopathy: MRI

[5] S Kuzuhara, et al. Subacute leucoencephalopathy induced by carmofur, a 5-fluorouracil derivative

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Keywords: Carmofur, HCFU supplier, DNA/RNA Synthesis, inhibitors, activators

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