All AbMole products are for research use only, cannot be used for human consumption.
5-Fluorouracil (5-FU) is a chemotherapy compound that is a pyrimidine analog which is used in the treatment of cancer. 5-Fluorouracil (5-FU) works through noncompetitive inhibition of thymidylate synthase. Fluorouracil IC50 values were observed across the National Cancer Institute NCI60 panel of human tumor cell lines, which exhibit a mean IC50 of 17.6 μM, with a range of 1~501 μM.
In vivo, 5-Fluorouracil (23 mg/kg, 3 times/week) for 14 days, induces accelerated gastrointestinal transit associated with acute intestinal inflammation at day 3 after the start of treatment, which may have led to persistent changes in the ENS observed after days 7 and 14 of treatment contributing to delayed gastrointestinal transit and colonic dysmotility.
ACS Nano. 2024 Nov 12;18(45):31055-31075.
Nanocarriers Targeting Circular RNA ADARB1 Boost Radiosensitivity of Nasopharyngeal Carcinoma through Synergically Promoting Ferroptosis
5-Fluorouracil purchased from AbMole
Modern Oncology. 2024 Jul 11;32(16):2981-2989.
Catechin enhanced the killing effects of 5-FU on gastric cancer cells through promoting ferroptosis of gastric cancer cells
5-Fluorouracil purchased from AbMole
Molecules. 2023 Apr 10;28(8), 3351.
The Large Molecular Weight Polysaccharide from Wild Cordyceps and Its Antitumor Activity on H22 Tumor-Bearing Mice
5-Fluorouracil purchased from AbMole
Drυg Discοv Ther. 2020 Sep 8;14(4):197-203.
MicroRNA analysis of NCI-60 human cancer cells indicates that miR-720 and miR-887 are potential therapeutic biomarkers for breast cancer
5-Fluorouracil purchased from AbMole
Cancer Biol Ther. 2018 Feb 5.
Buformin suppresses proliferation and invasion via AMPK/S6 pathway in cervical cancer and synergizes with paclitaxel
5-Fluorouracil purchased from AbMole
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Source | Drug Discoveries & Therapeutics 2020. Figure 4. 5-Fu (Abmole Bioscience Inc, Houston, TX, USA) |
| Method | MTT assay | |
| Cell Lines | A549, H460, H322M, MCF-7, T47-D and MDA-MB-231 cells | |
| Concentrations | - | |
| Incubation Time | 72 h | |
| Results | The current study verified that the anti-cancer effect of perifosine was significantly enhanced by inhibiting miR-720 and that the anti-cancer effect of 5-Fu was significantly enhanced by inhibiting miR-887 in breast cancer cells |
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Source | Cancer Biol Ther (2018). Figure 6. 5-FU (Abmole Bioscience, Shanghai, China) |
| Method | Buformin synergizes with chemotherapy | |
| Cell Lines | C33A cells | |
| Concentrations | 1 μM | |
| Incubation Time | ||
| Results | In C33A cells, low-dose buformin (1μM) significantly enhanced the anti-proliferative effects when combined with cisplatin, paclitaxel, or 5-FU |
| Molecular Weight | 130.08 |
| Formula | C4H3FN2O2 |
| CAS Number | 51-21-8 |
| Solubility (25°C) | DMSO 45 mg/mL (ultrasonic) Water 10 mg/mL (ultrasonic) |
| Storage | 4°C, protect from light, dry, sealed |
| Related DNA/RNA Synthesis Products |
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| Dencatistat
Dencatistat (P115) is an inhibitor of Cytidine Triphosphate Synthase 1 (CTPS1) with an IC50 value of ≤ 0.1 μM. |
| Antipain dihydrochloride
Antipain dihydrochloride is a protease inhibitor. Antipain dihydrochloride inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain dihydrochloride also restricts uterine DNA synthesis and function in mice. |
| Tetrahydrouridine
Tetrahydrouridine (THU) is potent inhibitor of cytidine deaminase (CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine. |
| Crisnatol
Crisnatol (BWA770U) is a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol shows in vitro cytotoxicity against human breast cancer cells. Crisnatol (BWA770U) is also an orally active and anticancer agent. |
| Caf1-IN-1
Caf1-IN-1 is inhibitor for ribonuclease Caf1 with an IC50 of 0.59 µM. Caf1-IN-1 is also a weak inhibitor for poly(A)-specific ribonuclease (PARN) with IC50 of 23.9 µM. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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