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5-fluorouracil

Cat. No. M2289
5-fluorouracil Structure
Synonym:

5-FU, Carac, Efudex; Adrucil

Size Price Availability Quantity
200mg USD 45  USD50 In stock
1g USD 54  USD60 In stock
2g USD 67.5  USD75 In stock
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Quality Control
Biological Activity

5-fluorouracil (5-FU) is a chemotherapy compound that is a pyrimidine analog which is used in the treatment of cancer. 5-fluorouracil (5-FU) works through noncompetitive inhibition of thymidylate synthase. Fluorouracil IC50 values were observed across the National Cancer Institute NCI60 panel of human tumor cell lines, which exhibit a mean IC50 of 17.6 μM, with a range of 1~501 μM.

In vivo, 5-fluorouracil (23 mg/kg, 3 times/week) for 14 days, induces accelerated gastrointestinal transit associated with acute intestinal inflammation at day 3 after the start of treatment, which may have led to persistent changes in the ENS observed after days 7 and 14 of treatment contributing to delayed gastrointestinal transit and colonic dysmotility.

Product Citations
Customer Product Validations & Biological Datas
Source Drug Discoveries & Therapeutics 2020. Figure 4. 5-Fu (Abmole Bioscience Inc, Houston, TX, USA)
Method MTT assay
Cell Lines A549, H460, H322M, MCF-7, T47-D and MDA-MB-231 cells
Concentrations -
Incubation Time 72 h
Results The current study verified that the anti-cancer effect of perifosine was significantly enhanced by inhibiting miR-720 and that the anti-cancer effect of 5-Fu was significantly enhanced by inhibiting miR-887 in breast cancer cells
Source Cancer Biol Ther (2018). Figure 6. 5-FU (Abmole Bioscience, Shanghai, China)
Method Buformin synergizes with chemotherapy
Cell Lines C33A cells
Concentrations 1 μM
Incubation Time
Results In C33A cells, low-dose buformin (1μM) significantly enhanced the anti-proliferative effects when combined with cisplatin, paclitaxel, or 5-FU
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 130.08
Formula C4H3FN2O2
CAS Number 51-21-8
Purity >99%
Solubility Water 2 mg/mL
Storage 4°C, protect from light, dry, sealed
References

Amphiphilic dendritic nanomicelle-mediated co-delivery of 5-fluorouracil and doxorubicin for enhanced therapeutic efficacy.
Han R, et al. J Drug Target. 2017 Feb;25(2):140-148. PMID: 27356094.

Gastrointestinal dysfunction and enteric neurotoxicity following treatment with anticancer chemotherapeutic agent 5-fluorouracil.
McQuade RM, et al. Neurogastroenterol Motil. 2016 Dec;28(12):1861-1875. PMID: 27353132.

Knockdown of NFBD1/MDC1 enhances chemosensitivity to cisplatin or 5-fluorouracil in nasopharyngeal carcinoma CNE1 cells.
Zeng Q, et al. Mol Cell Biochem. 2016 Jul;418(1-2):137-46. PMID: 27334757.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: 5-fluorouracil, 5-FU, Carac, Efudex; Adrucil supplier, DNA/RNA Synthesis, inhibitors

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