All AbMole products are for research use only, cannot be used for human consumption.
5-Fluorouracil (5-FU) is a chemotherapy compound that is a pyrimidine analog which is used in the treatment of cancer. 5-Fluorouracil (5-FU) works through noncompetitive inhibition of thymidylate synthase. Fluorouracil IC50 values were observed across the National Cancer Institute NCI60 panel of human tumor cell lines, which exhibit a mean IC50 of 17.6 μM, with a range of 1~501 μM.
In vivo, 5-Fluorouracil (23 mg/kg, 3 times/week) for 14 days, induces accelerated gastrointestinal transit associated with acute intestinal inflammation at day 3 after the start of treatment, which may have led to persistent changes in the ENS observed after days 7 and 14 of treatment contributing to delayed gastrointestinal transit and colonic dysmotility.
J Nanobiotechnology. 2025 Mar 28;23(1):252.
5-FU@HFn combined with decitabine induces pyroptosis and enhances antitumor immunotherapy for chronic myeloid leukemia
5-Fluorouracil purchased from AbMole
Patent. CN120695014A 2025 Nov 07; .
Patent. CN120695014A
5-Fluorouracil purchased from AbMole
ACS Nano. 2024 Nov 12;18(45):31055-31075.
Nanocarriers Targeting Circular RNA ADARB1 Boost Radiosensitivity of Nasopharyngeal Carcinoma through Synergically Promoting Ferroptosis
5-Fluorouracil purchased from AbMole
Modern Oncology. 2024 Jul 11;32(16):2981-2989.
Catechin enhanced the killing effects of 5-FU on gastric cancer cells through promoting ferroptosis of gastric cancer cells
5-Fluorouracil purchased from AbMole
Molecules. 2023 Apr 10;28(8), 3351.
The Large Molecular Weight Polysaccharide from Wild Cordyceps and Its Antitumor Activity on H22 Tumor-Bearing Mice
5-Fluorouracil purchased from AbMole
Drυg Discοv Ther. 2020 Sep 8;14(4):197-203.
MicroRNA analysis of NCI-60 human cancer cells indicates that miR-720 and miR-887 are potential therapeutic biomarkers for breast cancer
5-Fluorouracil purchased from AbMole
Cancer Biol Ther. 2018 Feb 5.
Buformin suppresses proliferation and invasion via AMPK/S6 pathway in cervical cancer and synergizes with paclitaxel
5-Fluorouracil purchased from AbMole
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Source | Drug Discoveries & Therapeutics 2020. Figure 4. 5-Fu (Abmole Bioscience Inc, Houston, TX, USA) |
| Method | MTT assay | |
| Cell Lines | A549, H460, H322M, MCF-7, T47-D and MDA-MB-231 cells | |
| Concentrations | - | |
| Incubation Time | 72 h | |
| Results | The current study verified that the anti-cancer effect of perifosine was significantly enhanced by inhibiting miR-720 and that the anti-cancer effect of 5-Fu was significantly enhanced by inhibiting miR-887 in breast cancer cells |
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Source | Cancer Biol Ther (2018). Figure 6. 5-FU (Abmole Bioscience, Shanghai, China) |
| Method | Buformin synergizes with chemotherapy | |
| Cell Lines | C33A cells | |
| Concentrations | 1 μM | |
| Incubation Time | ||
| Results | In C33A cells, low-dose buformin (1μM) significantly enhanced the anti-proliferative effects when combined with cisplatin, paclitaxel, or 5-FU |
| Molecular Weight | 130.08 |
| Formula | C4H3FN2O2 |
| CAS Number | 51-21-8 |
| Solubility (25°C) | DMSO 45 mg/mL (ultrasonic) Water 10 mg/mL (ultrasonic) |
| Storage | 4°C, protect from light, dry, sealed |
| Related DNA/RNA Synthesis Products |
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| Mizoribine
Mizoribine (Bredinin) is an imidazole nucleoside and an immunosuppressive agent with an IC50 of approximately 100 μM. Mizoribine inhibits replication of SARS-CoV with IC50s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively. |
| CDDP
Cisplatin is an inorganic platinum complex that inhibits DNA synthesis by forming DNA crosslinking agents, inactivates GPXs, reduces cell GSH and induces iron death in HCT116 and A549 cells. |
| Raltitrexed
Raltitrexed is an inhibitor of thymidylate synthase used in cancer chemotherapy. |
| Carmofur
Carmofur is a pyrimidine analog that is a prodrug of 5-fluorouracil (5-FU), which inhibits DNA Synthesis and has better antiproliferative activity than 5-FU. Carmofur is an inhibitor of Acidic Ceramidase (ASAH1) and a potential lead compound for non-cancer diseases such as Krabbe disease, acute lung injury (ALI), Parkinson's disease (PD), dementia, etc. Carmofur also has antifungal and antimicrobial properties. |
| CX-5461
CX-5461 (Pidnarulex) selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116 cells. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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