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Raltitrexed (Tomudex, ZD1694) is a novel quinazoline folate analog that selectively inhibits thymidylate synthase. Raltitrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells.
| Molecular Weight | 458.49 |
| Formula | C21H22N4O6S |
| CAS Number | 112887-68-0 |
| Solubility (25°C) | DMSO 78 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Bernard Royer, et al. Exposure-response analysis of Raltitrexed assessing liver toxicity
[2] Y Liu, et al. Raltitrexed-based chemotherapy for advanced colorectal cancer
[3] Veerle F Surmont, et al. Raltitrexed in mesothelioma
[4] Kenneth S Wilson, et al. Raltitrexed: optimism and reality
[5] E Van Cutsem, et al. Raltitrexed: current clinical status and future directions
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