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Methoxyamine HCl

Cat. No. M10541

All AbMole products are for research use only, cannot be used for human consumption.

Methoxyamine HCl Structure
Synonym:

TRC-102

Size Price Availability Quantity
1g USD 30  USD30 In stock
5g USD 50  USD50 In stock
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Biological Activity

Methoxyamine is an orally bioavailable small molecule inhibitor with potential adjuvant activity. Methoxyamine covalently binds to apurinic/apyrimidinic (AP) DNA damage sites and inhibits base excision repair (BER), which may result in an increase in DNA strand breaks and apoptosis.

Product Citations
Chemical Information
Molecular Weight 83.52
Formula CH6ClNO
CAS Number 593-56-6
Solubility (25°C) Soluble in Water
Soluble in ethanol
Storage 2-8°C, dry, sealed
References

[1] Tao Yan, et al. Mol Cancer Ther. Methoxyamine potentiates iododeoxyuridine-induced radiosensitization by altering cell cycle kinetics and enhancing senescence

[2] Lili Liu, et al. Curr Opin Investig Drugs. Therapeutic impact of methoxyamine: blocking repair of abasic sites in the base excision repair pathway

[3] Shuming Yang, et al. J Chromatogr B Analyt Technol Biomed Life Sci. Measurement of anti-cancer agent methoxyamine in plasma by tandem mass spectrometry with on-line sample extraction

[4] P Taverna, et al. Mutat Res. Methoxyamine potentiates DNA single strand breaks and double strand breaks induced by temozolomide in colon cancer cells

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Keywords: Methoxyamine HCl, TRC-102 supplier, DNA/RNA Synthesis, inhibitors, activators

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