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Methoxyamine HCl

Cat. No. M10541
Methoxyamine HCl Structure
Synonym:

TRC-102

Size Price Availability Quantity
500mg USD 70  USD70 In stock
1g USD 110  USD110 In stock
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Quality Control
  • Current batch:
  • Purity >98.5%
  • COA
  • MSDS
Biological Activity

Methoxyamine is an orally bioavailable small molecule inhibitor with potential adjuvant activity. Methoxyamine covalently binds to apurinic/apyrimidinic (AP) DNA damage sites and inhibits base excision repair (BER), which may result in an increase in DNA strand breaks and apoptosis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 83.52
Formula CH6ClNO
CAS Number 593-56-6
Purity >98.5%
Solubility Soluble in Water
Soluble in ethanol
Storage 2-8°C, dry, sealed
References

[1] Tao Yan, et al. Mol Cancer Ther. Methoxyamine potentiates iododeoxyuridine-induced radiosensitization by altering cell cycle kinetics and enhancing senescence

[2] Lili Liu, et al. Curr Opin Investig Drugs. Therapeutic impact of methoxyamine: blocking repair of abasic sites in the base excision repair pathway

[3] Shuming Yang, et al. J Chromatogr B Analyt Technol Biomed Life Sci. Measurement of anti-cancer agent methoxyamine in plasma by tandem mass spectrometry with on-line sample extraction

[4] P Taverna, et al. Mutat Res. Methoxyamine potentiates DNA single strand breaks and double strand breaks induced by temozolomide in colon cancer cells

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Methoxyamine HCl, TRC-102 supplier, DNA/RNA Synthesis, inhibitors

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