| Cat.No. | Name | Information |
|---|---|---|
| M2129 | Temozolomide | Temozolomide (TMZ) is an oral DNA methylating, chemotherapeutic agent. |
| M2223 | Cisplatin | Cisplatin is an inorganic platinum complex that inhibits DNA synthesis by forming DNA crosslinking agents, inactivates GPXs, reduces cell GSH and induces iron death in HCT116 and A549 cells. |
| M2289 | 5-Fluorouracil | 5-Fluorouracil (5-FU) is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. |
| M2288 | Carboplatin | Carboplatin (NSC 241240) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism. |
| M2292 | Cytarabine | Cytarabine (Cytosine arabinoside, AraC) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM. |
| M1716 | Gemcitabine Hydrochloride | Gemcitabine (Gemzar, LY188011) inhibits DNA synthesis with an IC50 of 0.06 µM. |
| M5680 | Gemcitabine | Gemcitabine (LY-188011; NSC 613327) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis. |
| M5277 | B02 | B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM). |
| M7515 | Brivudine | Brivudine is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication. |
| M9650 | Triazavirin | Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent, works by inhibiting the synthesis of viral RNA and DNA and replication of genomic fragments. |
| M21557 | RP-6685 | RP-6685 is a potent, selective and orally active inhibitor of DNA polymerase θ (Polθ) with an IC50 value of 5.8 nM (PicoGreen assay). RP-6685 showed antitumor effect in mouse tumor transplantation model. |
| M21517 | Supinoxin | Supinoxin (RX-5902) is a potent oral inhibitor of phosphorylated p68 RNA helicase (P-p68) and a first-in-class anti-cancer agent. Supinoxin induced apoptosis and inhibited the growth of TNBC cancer cell lines, with IC50 ranging from 10 nM to 20 nM. |
| M21168 | ART558 | ART558 is a nanomolar, highly potent, selective, low-molecular-weight, variant DNA polymerase active Polθ inhibitor (IC50=7.9 nM). ART558 can be used in cancer research. |
| M21143 | 5-Fluorouridine | 5-Fluorouridine is a metabolite of 5-fluorouracil, a potent inhibitor of nuclease autocleavage. 5-Fluorouridine binds to total and poly A RNA and has antiproliferative activity. 5-Fluorouridine induces apoptosis (cell death). |
| M15058 | Xanthosine 5'-monophosphate sodium salt | Xanthosine 5' -Monophosphate sodium Salt is an intermediate of purine metabolism and a product of rate-limiting step in guanosine production, which is of great significance in the synthesis of DNA, RNA and glycoproteins. |
| M13700 | Forodesine | Forodesine (BCX-1777) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. |
| M13655 | TK216 | TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor. TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity. |
| M13653 | RG7800 hydrochloride | RG7800 hydrochloride is an orally active SMN2 splicing modulator, with EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; RG7800 hydrochloride has the potential to treat spinal muscular atrophy. |
| M13651 | O6-Benzylguanine | O6-Benzylguanine, a guanine analog, is the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase (MGMT/AGT) inhibitor. |
| M13650 | ML-60218 | ML-60218 is a broad-spectrum RNA pol III inhibitor, with IC50s of 32 and 27 μM for Saccharomyces cerevisiae and human. |
| M13649 | Branaplam | Branaplam (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. |
| M13648 | Halofuginone hydrobromide | Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. |
| M13647 | Halofuginone | Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. |
| M13646 | Guanine | Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. |
| M13639 | Adenine hemisulfate | Adenine hemisulfate (6-Aminopurine hemisulfate), a purine, is one of the four nucleobases in the nucleic acid of DNA. |
| M13638 | Acelarin | Acelarin (NUC-1031) is a ProTide transformation and enhancement of the widely-used nucleoside analogue, gemcitabine. |
| M13637 | 5-Methylcytosine | 5-Methylcytosine is a well-characterized DNA modification, and is also predominantly in abundant non-coding RNAs in both prokaryotes and eukaryotes. |
| M13558 | Tipiracil | Tipiracil is a thymidine phosphorylase (TPase) inhibitor. |
| M13368 | IMT1B | IMT1B (LDC203974) is a highly specific human mitochondrial RNA polymerase (POLRMT) inhibitor that inhibits mitochondrial DNA (mtDNA) expression. IMT1B has antitumor effects. |
| M13367 | Metarrestin (ML246) | Metarrestin (ML246) is a first-in-class, oral active and specific perinucleolar compartment (PNC) inhibitor. It can destroy the nucleolus structure and inhibit the transcription of RNA polymerase (Pol) I. Metarrestin blocks the development of metastasis and prolongs survival in mouse cancer models. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
