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RG3039

Cat. No. M20884

All AbMole products are for research use only, cannot be used for human consumption.

RG3039 Structure
Synonym:

PF-06687859, PF 6687859, Quinazoline 495

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Quality Control & Documentation
Biological Activity

RG3039 (PF-06687859, PF 6687859, Quinazoline 495) is an orally bioavailable and brain-penetrant inhibitor of the mRNA decapping enzyme DcpS with IC50 of 4.2 nM and IC90 of 40 nM, respectively.

Chemical Information
Molecular Weight 432.35
Formula C21H23Cl2N5O
CAS Number 1005504-62-0
Solubility (25°C) DMSO 3 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jake C Swartzel, et al. ACS Chem Biol. Targeted Degradation of mRNA Decapping Enzyme DcpS by a VHL-Recruiting PROTAC

[2] Takuji Yamauchi, et al. Cancer Cell. Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS

[3] Alyssa N Calder, et al. J Med Chem. Small Molecules in Development for the Treatment of Spinal Muscular Atrophy

[4] Rocky G Gogliotti, et al. Hum Mol Genet. The DcpS inhibitor RG3039 improves survival, function and motor unit pathologies in two SMA mouse models

[5] James P Van Meerbeke, et al. Hum Mol Genet. The DcpS inhibitor RG3039 improves motor function in SMA mice

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Keywords: RG3039, PF-06687859, PF 6687859, Quinazoline 495 supplier, DNA/RNA Synthesis, inhibitors, activators

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