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D-I03

Cat. No. M21650

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D-I03 Structure
Synonym:

D103

Size Price Availability Quantity
5mg USD 88  USD88 In stock
10mg USD 152  USD152 In stock
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Quality Control & Documentation
Biological Activity

D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM. D-I03 specifically inhibits RAD52-dependent single-strand annealing (SSA) and D-loop formation with IC50s of 5 µM and 8 µM, respectively. D-I03 suppresses growth of BRCA1- and BRCA2-deficient cells and inhibits formation of damage-induced RAD52 foci, but does not effect on RAD51 foci induced by Cisplatin. D-I03 inhibits RAD52 foci formation induced by cisplatin in BCR-ABL1-positive BRCA1-deficient 32Dcl3 murine hematopoietic cell line that expresses GFP-RAD52. In the presence of D-I03 (2.5 μM), the fraction of cells with RAD52 foci is decreased, from 38.7% to 171%; while the fraction of Cisplatin-treated cells without foci is increased from 48.4% to 71.9%.

Chemical Information
Molecular Weight 428.64
Formula C23H36N6S
CAS Number 688342-78-1
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
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  Catalog
Abmole Inhibitor Catalog




Keywords: D-I03, D103 supplier, DNA/RNA Synthesis, inhibitors, activators

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