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 About 25 results found for searched term "D-I03" (0.031 seconds)

Cat.No.  Name Target
M1733 TG101348 JAK
TG101348 is a selective small-molecule Janus kinase 2 (JAK2) inhibitor with IC50 of 3 nM.
M1763 Mirdametinib (PD0325901) MEK
Mirdametinib (PD0325901) is a highly potent and selective MEK inhibitor with an IC50 in C26 cells of 0.33nM.
M1781 Adezmapimod (SB203580) p38 MAPK
RWJ 64809; PB 203580; Adezmapimod
Adezmapimod (SB203580) is a P38 MAPK inhibitor with an IC50 of 0.3-0.5 μM, which is 10 times less selective than SAPK3(106T) and SAPK4(106T), and inhibits PKB phosphorylation with an IC50 of 3-5 μM.
M2408 Atomoxetine hydrochloride 5-HT Receptor
Tomoxetine hydrochloride; LY 139603; (R)-Tomoxetine hydrochloride
Atomoxetine is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.
M2468 Brimonidine Tartrate Adrenergic Receptor
Brimonidine tartrate; AGN190342 tartrate; UK14304 tartrate
Brimonidine Tartrate is a highly selective α-adrenergic receptor antagonist with an EC50 of 0.45 nM for α2A adrenoreceptor, and has been used to study open-angle glaucoma or ocular hypertension.
M4152 Daidzin Dehydrogenase
Daidzoside; NPI-031D; Daidzein 7-O-glucoside
Daidzin is an isoflavone that has anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities; directly inhibits mitochondrial aldehyde dehydrogenase 2 (IC50 = 80 nM) and is an effective anti-dipsotropic isoflavone.
M4907 Doxycycline Hyclate MMP
Doxycycline hydrochloride hemiethanolate hemihydrate; WC2031
Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections.
M4968 Mitiglinide calcium hydrate Potassium Channel
KAD-1229 calcium hydrate; S-21403 calcium hydrate
Miglinide calcium hydrate is a compound used to study type 2 diabetes mellitus. It is a highly selective KATP channel antagonist.
M6010 Tiagabine HCl GABA Receptor
Gabitril hydrochloride, NO050328 hydrochloride, NO328 hydrochloride, TGB hydrochloride
Tiagabine Hydrochloride is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor.
M8711 Delafloxacin Others
Delafloxacinum; RX-3341; WQ-3034; ABT492; ABT 492; ABT-492
Delafloxacin is a fluoroquinolone antibiotic active against both Gram-negative and Gram-positive bacteria such as MRSA.
M8833 Brimonidine (UK 14304) Adrenergic Receptor
Brimonidine; AGN190342; UK14304
Brimonidine (UK 14304) is an α2-adrenoceptor agonist.
M9004 WDR5-0103 Histone Methyltransferase
WD-Repeat Protein 5-0103
WDR5-0103 is a small molecule that binds a peptide-binding pocket on WDR5 (Kd = 450 nM), inhibiting the catalytic activity of the MLL core complex in vitro (IC50 = 39 µM).
M9696 Dihydroethidium Fluorescent Dye
Hydroethidine; PD-MY 003; DHE
Dihydroethidium (also known as Hydroethidine and PD-MY 003) is a cell-permeable blue fluorescent dye.
M9749 Cotadutide acetate Glucagon Receptor
MEDI0382 acetate
Cotadutide acetate is a potent peptide dual agonist of glucagon-like peptide-1 (GLP-1) and glucagon receptor, with EC50 values of 6.9 pM and 10.2 pM, respectively.
M9850 BODIPY 493/503 Fluorescent Dye
BODIPY 493/503 is a lipophilic fluorescent probe that localizes to polar lipids and can be used to label cellular neutral lipid contents, particularly those localized to lipid droplets, in live and fixed cells.
M13588 Methotrexate disodium Antifolate
Amethopterin disodium; CL14377 disodium; WR19039 disodium
Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis.
M14270 Disopyramide Sodium Channel
Dicorantil; SC-7031
Disopyramide (Dicorantil) is a class IA antiarrhythmic drug with efficacy in ventricular and atrial arrhythmias.
M19868 Ceftaroline Fosamil Anti-infection
CX-0903; DSP-5990; PPI-0903; TAK-599; Teflaro; Zinforo
Ceftaroline fosamil (CX-0903, DSP-5990, PPI-0903, TAK-599, Teflaro, Zinforo) is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA).

M21650 D-I03 DNA/RNA Synthesis
D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM. D-I03 specifically inhibits RAD52-dependent single-strand annealing (SSA) and D-loop formation with IC50s of 5 µM and 8 µM, respectively.
M24532 Sifalimumab Others
MEDI-545; MDX 1103
Sifalimumab (MEDI-545) is an anti-IFNα monoclonal antibody. Sifalimumab suppresses the abnormal immune activity by binding to multiple interferon-alpha (IFNα) subtypes. Sifalimumab can be used in systemic lupus erythematosus (SLE) research.
M25460 Zasocitinib JAK
NDI-034858; TAK-279
Zasocitinib (NDI-034858) is a highly selective, orally active TYK2 inhibitor, target TYK2 JH2 domain with binding constant Kd of <200 pM.
M28279 Fedratinib hydrochloride hydrate JAK
TG-101348 hydrochloride hydrate; SAR 302503 hydrochloride hydrate
Fedratinib hydrochloride hydrate (TG-101348 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor with IC50s of 3 nM for both JAK2 and JAK2V617F kinase. Fedratinib hydrochloride hydrate shows 35- and 334-fold selectivity over JAK1 and JAK3, respectively.
M40847 NDI-031407 JAK
NDI-031407 is a TYK2 inhibitor for studies related to endocrine metabolic diseases and psoriasis.
M40848 NDI-031301 JAK
NDI-031301 is a TYK2 inhibitor.
M40849 NDI-031232 JAK
NDI-031232 is a TYK2 inhibitor.

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