About 28 results found for searched term "D-I03" (0.102 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1733 | TG101348 | JAK |
| Fedratinib; SAR302503 | ||
| TG101348 is a selective small-molecule Janus kinase 2 (JAK2) inhibitor with IC50 of 3 nM. | ||
| M1763 | Mirdametinib (PD0325901) | MEK |
| Mirdametinib；PD325901 | ||
| Mirdametinib (PD0325901) is a highly potent and selective MEK inhibitor with an IC50 in C26 cells of 0.33nM. | ||
| M1781 | Adezmapimod (SB203580) | p38 MAPK |
| RWJ 64809; PB 203580; Adezmapimod | ||
| Adezmapimod (SB203580) is a P38 MAPK inhibitor with an IC50 of 0.3-0.5 μM, which is 10 times less selective than SAPK3(106T) and SAPK4(106T), and inhibits PKB phosphorylation with an IC50 of 3-5 μM. | ||
| M1938 | Daptomycin | Antibiotic |
| Cubicin; Dapcin; LY146032 | ||
| Daptomycin is the first member of a new class of bactericidal antibiotics, the cyclic lipopeptides. | ||
| M2408 | Atomoxetine hydrochloride | 5-HT Receptor |
| Tomoxetine hydrochloride; LY 139603; (R)-Tomoxetine hydrochloride | ||
| Atomoxetine is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters. | ||
| M2468 | Brimonidine Tartrate | Adrenergic Receptor |
| Brimonidine tartrate; AGN190342 tartrate; UK14304 tartrate | ||
| Brimonidine Tartrate is a highly selective α-adrenergic receptor antagonist with an EC50 of 0.45 nM for α2A adrenoreceptor, and has been used to study open-angle glaucoma or ocular hypertension. | ||
| M2991 | Cutamesine dihydrochloride | Sigma Receptor |
| AGY94806 dihydrochloride; SA 4503 dihydrochloride | ||
| Cutamesine dihydrochloride (SA4503 dihydrochloride; AGY94806 dihydrochloride) is a novel and selective opioid sigma1 receptor agonist with IC50 of 17.4 nM. | ||
| M4152 | Daidzin | Dehydrogenase |
| Daidzoside; NPI-031D; Daidzein 7-O-glucoside | ||
| Daidzin is an isoflavone that has anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities; directly inhibits mitochondrial aldehyde dehydrogenase 2 (IC50 = 80 nM) and is an effective anti-dipsotropic isoflavone. | ||
| M4907 | Doxycycline Hyclate | MMP |
| Doxycycline hydrochloride hemiethanolate hemihydrate; WC2031 | ||
| Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. | ||
| M4968 | Mitiglinide calcium hydrate | Potassium Channel |
| KAD-1229 calcium hydrate; S-21403 calcium hydrate | ||
| Miglinide calcium hydrate is a compound used to study type 2 diabetes mellitus. It is a highly selective KATP channel antagonist. | ||
| M6010 | Tiagabine HCl | GABA Receptor |
| Gabitril hydrochloride, NO050328 hydrochloride, NO328 hydrochloride, TGB hydrochloride | ||
| Tiagabine Hydrochloride is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor. | ||
| M7410 | THIP hydrochloride | GABA Receptor |
| Gaboxadol hydrochloride; Lu 02-030 HCl | ||
| THIP hydrochloride (Gaboxadol hydrochloride) is a potent agonist of the GABAA receptor and an antagonist of GABAC receptors (IC50=25 μM). Gaboxadol hydrochloride displays a partial agonist efficacy on subunit α1β2γ2 with an ED50 value of 143 µM, a full agonist efficacy at α5 subunit (ED50=28-129 µM) and a superagonist efficacy at α4β3δ (ED50=6 µM). | ||
| M8711 | Delafloxacin | Anti-infection |
| ABT-492; Delafloxacinum; RX-3341; WQ-3034; ABT492 | ||
| Delafloxacin is a fluoroquinolone antibiotic active against both Gram-negative and Gram-positive bacteria such as MRSA. | ||
| M9004 | WDR5-0103 | Histone Methyltransferase |
| WD-Repeat Protein 5-0103 | ||
| WDR5-0103 is a small molecule that binds a peptide-binding pocket on WDR5 (Kd = 450 nM), inhibiting the catalytic activity of the MLL core complex in vitro (IC50 = 39 µM). | ||
| M9696 | Dihydroethidium | Fluorescent Dye |
| Hydroethidine; PD-MY 003; DHE | ||
| Dihydroethidium (also known as Hydroethidine and PD-MY 003) is a cell-permeable blue fluorescent dye. | ||
| M9749 | Cotadutide acetate | GLP Receptor |
| MEDI0382 acetate | ||
| Cotadutide acetate is a potent peptide dual agonist of glucagon-like peptide-1 (GLP-1) and glucagon receptor, with EC50 values of 6.9 pM and 10.2 pM, respectively. | ||
| M9850 | ABDP 493/503 | Fluorescent Dye |
| ABDP 493/503 (same as BODIPY 493/503) is a lipophilic fluorescent probe that localizes to polar lipids and can be used to label cellular neutral lipid contents, particularly those localized to lipid droplets, in live and fixed cells. | ||
| M13588 | Methotrexate disodium | Antifolate |
| Amethopterin disodium; CL14377 disodium; WR19039 disodium | ||
| Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. | ||
| M14270 | Disopyramide | Sodium Channel |
| Dicorantil; SC-7031 | ||
| Disopyramide (Dicorantil) is a class IA antiarrhythmic drug with efficacy in ventricular and atrial arrhythmias. | ||
| M19868 | Ceftaroline Fosamil | Anti-infection |
| CX-0903; DSP-5990; PPI-0903; TAK-599; Teflaro; Zinforo | ||
| Ceftaroline fosamil (CX-0903, DSP-5990, PPI-0903, TAK-599, Teflaro, Zinforo) is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). | ||
| M21650 | D-I03 | DNA/RNA Synthesis |
| D103 | ||
| D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM. D-I03 specifically inhibits RAD52-dependent single-strand annealing (SSA) and D-loop formation with IC50s of 5 µM and 8 µM, respectively. | ||
| M24532 | Sifalimumab | Others |
| MEDI-545; MDX 1103 | ||
| Sifalimumab (MEDI-545) is an anti-IFNα monoclonal antibody. Sifalimumab suppresses the abnormal immune activity by binding to multiple interferon-alpha (IFNα) subtypes. Sifalimumab can be used in systemic lupus erythematosus (SLE) research. | ||
| M25460 | Zasocitinib | JAK |
| NDI-034858; TAK-279 | ||
| Zasocitinib (NDI-034858) is a highly selective, orally active TYK2 inhibitor, target TYK2 JH2 domain with binding constant Kd of <200 pM. | ||
| M28279 | Fedratinib hydrochloride hydrate | JAK |
| TG-101348 hydrochloride hydrate; SAR 302503 hydrochloride hydrate | ||
| Fedratinib hydrochloride hydrate (TG-101348 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor with IC50s of 3 nM for both JAK2 and JAK2V617F kinase. Fedratinib hydrochloride hydrate shows 35- and 334-fold selectivity over JAK1 and JAK3, respectively. | ||
| M31215 | Cotadutide | Glucagon Receptor |
| MEDI0382 | ||
| Cotadutide (MEDI0382) is a potent dual agonist of glucagon-like peptide-1 (GLP-1) and GCGR with EC50 values of 6.9 pM and 10.2 pM, respectively. Cotadutide can be used in the research of obesity and type 2 diabetes (T2D). | ||
| M40847 | NDI-031407 | JAK |
| NDI-031407 is a TYK2 inhibitor for studies related to endocrine metabolic diseases and psoriasis. | ||
| M40848 | NDI-031301 | JAK |
| NDI-031301 is a TYK2 inhibitor. | ||
| M40849 | NDI-031232 | JAK |
| NDI-031232 is a TYK2 inhibitor. | ||
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