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Cotadutide acetate is a potent peptide dual agonist of glucagon-like peptide-1 (GLP-1) and glucagon receptor, with EC50 values of 6.9 pM and 10.2 pM, respectively. Cotadutide acetate (MEDI0382 acetate) shows EC50 values of 6.9 and 10.2 pM as measured by cAMP generation in CHO cells over‐expressing human recombinant GLP‐1 or glucagon receptors in the presence of 0.1% BSA, which are within 10‐fold of the native ligands.
| Molecular Weight | 3788.14 |
| Formula | C169H256N42O57 |
| CAS Number | 1686108-82-6(free base) |
| Solubility (25°C) | DMSO 2 mg/mL |
| Storage | -20°C, dry, sealed |
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