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Cotadutide

Cat. No. M31215

All AbMole products are for research use only, cannot be used for human consumption.

Cotadutide Structure
Synonym:

MEDI0382

Size Price Availability Quantity
1mg USD 185  USD185 In stock
5mg USD 550  USD550 In stock
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Quality Control & Documentation
Biological Activity

Cotadutide (MEDI0382) is a potent dual agonist of glucagon-like peptide-1 (GLP-1) and GCGR with EC50 values of 6.9 pM and 10.2 pM, respectively. Cotadutide can be used in the research of obesity and type 2 diabetes (T2D).

Chemical Information
Molecular Weight 3728.09
Formula C167H252N42O55
CAS Number 1686108-82-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ilitch Aquino Marcondes-de-Castro, et al. J Mol Endocrinol. Cotadutide effect in liver and adipose tissue in obese mice

[2] Ye Guan, et al. Clin Pharmacokinet. Population Pharmacokinetics of Cotadutide in Subjects with Type 2 Diabetes

[3] Rajaa Nahra, et al. Diabetes Care. Effects of Cotadutide on Metabolic and Hepatic Parameters in Adults With Overweight or Obesity and Type 2 Diabetes: A 54-Week Randomized Phase 2b Study

[4] Michelle L Boland, et al. Nat Metab. Resolution of NASH and hepatic fibrosis by the GLP-1R/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis

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Keywords: Cotadutide, MEDI0382 supplier, Glucagon Receptor, inhibitors, activators

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