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PF-06291874

Cat. No. M8113

All AbMole products are for research use only, cannot be used for human consumption.

PF-06291874 Structure
Size Price Availability Quantity
10mM*1mL in DMSO USD 75  USD75 In stock
5mg USD 70  USD70 In stock
10mg USD 98  USD98 In stock
25mg USD 210  USD210 In stock
50mg USD 380  USD380 In stock
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Quality Control & Documentation
Biological Activity

PF-06291874 is an orally active, potent and selective glucagon receptor antagonist. PF-06291874 exhibits a robust glucose reductions in subjects with type 2 diabetes mellitus.

Chemical Information
Molecular Weight 503.51
Formula C26H28F3N3O4
CAS Number 1393124-08-7
Solubility (25°C) DMSO: 15 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Lee EC, et al. Bioorg Med Chem Lett. Identification of a novel conformationally constrained glucagon receptor antagonist.

[2] Guzman-Perez A, et al. Bioorg Med Chem Lett. The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus.

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Keywords: PF-06291874 supplier, Glucagon Receptor, inhibitors, activators

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