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Tiagabine HCl

Cat. No. M6010
Tiagabine HCl Structure
Synonym:

Gabitril hydrochloride, NO050328 hydrochloride, NO328 hydrochloride, TGB hydrochloride

Size Price Availability Quantity
10mg USD 54  USD60 In stock
50mg USD 130.5  USD145 In stock
100mg USD 207  USD230 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Tiagabine Hydrochloride is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 412.01
Formula C20H25NO2S2.HCl
CAS Number 145821-59-6
Purity >98%
Solubility 82 mg/mL in DMSO
Storage at -20°C
References

The effect of GABA transporter 1 (GAT1) inhibitor, tiagabine, on scopolamine-induced memory impairments in mice.
Sałat K, et al. Pharmacol Rep. 2015 Dec;67(6):1155-62. PMID: 26481535.

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Keywords: Tiagabine HCl, Gabitril hydrochloride, NO050328 hydrochloride, NO328 hydrochloride, TGB hydrochloride supplier, GABA Receptor, inhibitors

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