| Cat.No. | Name | Information |
|---|---|---|
| M2347 | (+)-Bicuculline | (+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels. |
| M31393 | DL-Menthol | DL-Menthol is a cyclic monoterpene alcohol that is also associated with GABAA receptor activation and has local anesthetic activity. |
| M29494 | Fasedienol | Fasedienol is a neurochemical stimulator of the vomeronasal organ (VON). Fasedienol alleviates the symptoms of PMS and anxiety. |
| M21509 | Afizagabar | Afizagabar (S44819) is a first-in-class, competitive and selective α5-GABAAR antagonist with an IC50 value of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. |
| M21364 | CNS 7056 | CNS 7056 is a short-acting GABAa receptor agonist used in general anesthesia. |
| M19287 | a-Asarone | alpha-Asarone (α-Asarone) is one of the main psychoactive compounds, and possesses an antidepressant-like activity in mice. |
| M19236 | Arecaidine | Arecaidine, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake. |
| M14224 | Vigabatrin hydrochloride | Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. |
| M14221 | THIP | THIP (Gaboxadol) is a selective δ-aminobutyric acid type A receptor (δ-GABAAR) agonist, functionally selective GABAAR ligand, exhibits agonism at α4β1δ, α4β3δ and weak antagonism at αβγ and α4β2δ GABAARs. |
| M14220 | Picrotoxin | Picrotoxin (Cocculin) is a natural noncompetitive antagonist of GABAA receptor, binds to the interface pocket on the GABAR. Picrotoxin (Cocculin) causes overstimulation and induces convulsions. |
| M14219 | NS11394 | NS11394 is an orally active and unique subtype-selective GABAA positive allosteric receptor (PAM), with a Ki of ~0.5 nM. |
| M14214 | γ-Aminobutyric acid | γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain, binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors). |
| M11530 | Guvacine | Guvacine, an alkaloid found in areca nut, is an effective inhibitor of GABA uptake. Guvacine inhibited rat GAT-1 with IC50 values of 39 μM, 58 μM and 378 μM, respectively. |
| M11353 | 6‴-Feruloylspinosin | 6‴-Feruloylspinosin is a flavonoid isolated from the seeds of Ziziphus jujuba. In rat hippocampal neurons, 6‴ -feruloylspinosin can cross the blood-brain barrier and enhance the mRNA expression of GABAAα1, GABAAα5 and GABABR1. |
| M11220 | 4-Aminobutyrate | |
| M10390 | Aminooxy-acetic acid (AOA) | Aminooxy-acetic acid (AOA) is a GABA transaminase (GABA-T) inhibitor (Ki = 9.16 μM) that induces GABA accumulation in the brain. It also inhibits cystathionine β synthase (CBS) and cystathionine γ lyase (CSE) with IC50 values of 8.5 and 1.1 μM, respectively. Aminooxyacetic acid (Carboxymethoxylamine) is a malate-aspartate shuttle (MAS) inhibitor. |
| M10343 | Putrescine | Putrescine is a GABA precursor in many biological systems. |
| M10326 | Zuranolone | Zuranolone also known as SAGE-217, is a potent GABAA receptor agonist with EC50 values of 296 nM and 163 nM for α1β2γ2 and α4β3δ GABAA receptors. |
| M9874 | SSD114 hydrochloride | SSD114 hydrochloride is a GABAB receptor positive allosteric modulator. |
| M9856 | Pipequaline | Pipequaline (PK-8165) is a partial benzodiazepine receptor agonist with anxiolytic activity. |
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