| Cat.No. | Name | Information |
|---|---|---|
| M5653 | Flumazenil | Flumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses. |
| M5442 | Baclofen | Baclofen is an orally active, selective metabotropic GABAB receptor (GABABR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research. |
| M2347 | (+)-Bicuculline | (+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels. |
| M55450 | Pregabalin-d4 | Pregabalin-d4 |
| M45177 | 5-Aminovaleric acid | 5-Aminovaleric acid is a GABA receptor antagonist. |
| M45171 | L-2,4-Diaminobutyric acid dihydrochloride | L-2,4-Diaminobutyric acid dihydrochloride inhibits GABA transaminase activity, resulting in elevated GABA levels, and exhibits ex vivo antitumor activity against mouse fibrosarcoma cells. In addition, L-2,4-Diaminobutyric acid dihydrochloride can be used as an internal standard for amino acid analysis. |
| M42184 | γ-Acetylenic GABA hydrochloride | γ-Acetylenic GABA (GAG) hydrochloride is an irreversible inhibitor of GABA-transaminase. |
| M31393 | DL-Menthol | DL-Menthol is a cyclic monoterpene alcohol that is also associated with GABAA receptor activation and has local anesthetic activity. |
| M30609 | FG 7142 | FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex. |
| M29976 | Valerenic acid | Valerenic acid ((-)-Valerenic Acid), a sesquiterpenoid, is an orally active positive allosteric modulator of GABAA receptors. Valerenic acid is also a partial agonist of the 5-HT5a receptor. Valerenic acid mediates anxiolytic activity via GABAA receptors containing the β3 subunit. Valerenic acid also exhibits potent antioxidant properties. |
| M29494 | Fasedienol | Fasedienol is a neurochemical stimulator of the vomeronasal organ (VON). Fasedienol alleviates the symptoms of PMS and anxiety. |
| M28740 | Cipepofol | Cipepofol (HSK3486), a psychomotor stabilizing agent, is a gamma-aminobutyric acid (GABA) receptor potentiator. |
| M27944 | Broflanilide | Broflanilide is a potential insecticide and metabolized to Desmethyl-Broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin (RDL) GABA Receptor, and inhibits S. litura RDL GABAR, with an IC50 value of 1.3 nM. |
| M21509 | Afizagabar | Afizagabar (S44819) is a first-in-class, competitive and selective α5-GABAAR antagonist with an IC50 value of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. |
| M21364 | CNS 7056 | CNS 7056 is a short-acting GABAa receptor agonist used in general anesthesia. |
| M20438 | Phenibut | Phenibut, a GABA analogue, is a central nervous system depressant with anxiolytic and sedative effects. |
| M19287 | a-Asarone | alpha-Asarone (α-Asarone) is one of the main psychoactive compounds, and possesses an antidepressant-like activity in mice. |
| M19236 | Arecaidine | Arecaidine, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake. |
| M18259 | Arecaidine hydrochloride | Arecaidine hydrochloride |
| M14224 | Vigabatrin hydrochloride | Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. |
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