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GABA Receptor GABA Receptor

Cat.No.  Name Information
M2347 (+)-Bicuculline (+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.
M31393 DL-Menthol DL-Menthol is a cyclic monoterpene alcohol that is also associated with GABAA receptor activation and has local anesthetic activity.
M29494 Fasedienol Fasedienol is a neurochemical stimulator of the vomeronasal organ (VON). Fasedienol alleviates the symptoms of PMS and anxiety.
M21509 Afizagabar Afizagabar (S44819) is a first-in-class, competitive and selective α5-GABAAR antagonist with an IC50 value of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2.
M21364 CNS 7056 CNS 7056 is a short-acting GABAa receptor agonist used in general anesthesia.
M19287 a-Asarone alpha-Asarone (α-Asarone) is one of the main psychoactive compounds, and possesses an antidepressant-like activity in mice.
M19236 Arecaidine Arecaidine, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake.
M14224 Vigabatrin hydrochloride Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor.
M14221 THIP THIP (Gaboxadol) is a selective δ-aminobutyric acid type A receptor (δ-GABAAR) agonist, functionally selective GABAAR ligand, exhibits agonism at α4β1δ, α4β3δ and weak antagonism at αβγ and α4β2δ GABAARs.
M14220 Picrotoxin Picrotoxin (Cocculin) is a natural noncompetitive antagonist of GABAA receptor, binds to the interface pocket on the GABAR. Picrotoxin (Cocculin) causes overstimulation and induces convulsions.
M14219 NS11394 NS11394 is an orally active and unique subtype-selective GABAA positive allosteric receptor (PAM), with a Ki of ~0.5 nM.
M14214 γ-Aminobutyric acid γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain, binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors).
M11530 Guvacine Guvacine, an alkaloid found in areca nut, is an effective inhibitor of GABA uptake. Guvacine inhibited rat GAT-1 with IC50 values of 39 μM, 58 μM and 378 μM, respectively.
M11353 6‴-Feruloylspinosin 6‴-Feruloylspinosin is a flavonoid isolated from the seeds of Ziziphus jujuba. In rat hippocampal neurons, 6‴ -feruloylspinosin can cross the blood-brain barrier and enhance the mRNA expression of GABAAα1, GABAAα5 and GABABR1.
M11220 4-Aminobutyrate
M10390 Aminooxy-acetic acid (AOA) Aminooxy-acetic acid (AOA) is a GABA transaminase (GABA-T) inhibitor (Ki = 9.16 μM) that induces GABA accumulation in the brain. It also inhibits cystathionine β synthase (CBS) and cystathionine γ lyase (CSE) with IC50 values of 8.5 and 1.1 μM, respectively. Aminooxyacetic acid (Carboxymethoxylamine) is a malate-aspartate shuttle (MAS) inhibitor.
M10343 Putrescine Putrescine is a GABA precursor in many biological systems.
M10326 Zuranolone Zuranolone also known as SAGE-217, is a potent GABAA receptor agonist with EC50 values of 296 nM and 163 nM for α1β2γ2 and α4β3δ GABAA receptors.
M9874 SSD114 hydrochloride SSD114 hydrochloride is a GABAB receptor positive allosteric modulator.
M9856 Pipequaline Pipequaline (PK-8165) is a partial benzodiazepine receptor agonist with anxiolytic activity.

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