| Cat.No. | Name | Information |
|---|---|---|
| M2347 | (+)-Bicuculline | (+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels. |
| M14214 | γ-Aminobutyric acid | γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain, binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors). |
| M11530 | Guvacine | Guvacine, an alkaloid found in areca nut, is an effective inhibitor of GABA uptake. Guvacine inhibited rat GAT-1 with IC50 values of 39 μM, 58 μM and 378 μM, respectively. |
| M11353 | 6‴-Feruloylspinosin | 6‴-Feruloylspinosin is a flavonoid isolated from the seeds of Ziziphus jujuba. In rat hippocampal neurons, 6‴ -feruloylspinosin can cross the blood-brain barrier and enhance the mRNA expression of GABAAα1, GABAAα5 and GABABR1. |
| M11220 | 4-Aminobutyrate | |
| M10390 | Aminooxy-acetic acid (AOA) | Aminooxy-acetic acid (AOA) is a GABA transaminase (GABA-T) inhibitor (Ki = 9.16 μM) that induces GABA accumulation in the brain. It also inhibits cystathionine β synthase (CBS) and cystathionine γ lyase (CSE) with IC50 values of 8.5 and 1.1 μM, respectively. Aminooxyacetic acid (Carboxymethoxylamine) is a malate-aspartate shuttle (MAS) inhibitor. |
| M10326 | Zuranolone | Zuranolone also known as SAGE-217, is a potent GABAA receptor agonist with EC50 values of 296 nM and 163 nM for α1β2γ2 and α4β3δ GABAA receptors. |
| M9874 | SSD114 hydrochloride | SSD114 hydrochloride is a GABAB receptor positive allosteric modulator. |
| M9856 | Pipequaline | Pipequaline (PK-8165) is a partial benzodiazepine receptor agonist with anxiolytic activity. |
| M9411 | AZD-7325 | AZD-7325 is a GABA-Aα2,3 -selective receptor modulator. |
| M9188 | Clomethiazole | Clomethiazole is a positive allosteric modulator at the barbiturate/picrotoxin site of the GABAA receptor. |
| M9127 | ONO-8590580 | ONO-8590580 is a GABAAα5 negative allosteric modulator which enhances long-term potentiation and improves cognitive deficits in preclinical models. |
| M9114 | LAU159 | LAU159 is a potent, functionally selective α6β3γ2 GABAA receptor modulator. |
| M8879 | Aminooxy-acetic acid (AOA) hemihydrochloride | Aminooxyacetic acid hemihydrochloride is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T. |
| M8216 | Securinine | Securinine is an alkaloid widely in traditional folk medicine, it is a GABAA receptor antagonist. |
| M8027 | Brexanolone | Brexanolone (Allopregnanolone) is a positive allosteric modulator of GABAA chloride channel. |
| M7813 | Isoguvacine hydrochloride | Isoguvacine hydrochloride is a GABAA receptor agonist. |
| M7691 | Chlormethiazole hydrochloride | Chlormethiazole hydrochloride is a GABAA agonist; glycine receptor modulator. Clomethiazole hydrochloride is neuroprotective and prevents the degeneration of serotonergic nerve terminals induced by 3,4-methylenedioxymethamphetamine (MDMA). |
| M7607 | 5α-Androst-16-en-3α-ol | 5alpha-androst-16-en-3alp |
| M7442 | U 93631 | U 93631 is a gABA A receptor antagonist. |
| M7410 | THIP hydrochloride | THIP hydrochloride (Gaboxadol hydrochloride) is a potent agonist of the GABAA receptor and an antagonist of GABAC receptors (IC50=25 μM). Gaboxadol hydrochloride displays a partial agonist efficacy on subunit α1β2γ2 with an ED50 value of 143 µM, a full agonist efficacy at α5 subunit (ED50=28-129 µM) and a superagonist efficacy at α4β3δ (ED50=6 µM). |
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