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NS11394

Cat. No. M14219

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NS11394 Structure
Size Price Availability
5mg USD 95  USD95 4-7 Days
10mg USD 150  USD150 4-7 Days
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Quality Control & Documentation
Biological Activity

NS11394 is an orally active and unique subtype-selective GABAA positive allosteric receptor (PAM), with a Ki of ~0.5 nM. NS11394 shows a selectivity profile in the order of GABAA-5 > α3 > α2 > α1-containing receptors. NS11394 has anxiolytic and anti-inflammatory properties.

Chemical Information
Molecular Weight 353.42
CAS Number 951650-22-9
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Christine Sprte, et al. The α2β3γ2 GABA A receptor preferring agonist NS11394 aggravates dystonia in the phenotypic dt sz model

[2] Gordon Munro, et al. GABA(A) receptor modulation: potential to deliver novel pain medicines?

[3] Martine Hofmann, et al. Assessment of the effects of NS11394 and L-838417, α2/3 subunit-selective GABA(A) [corrected] receptor-positive allosteric modulators, in tests for pain, anxiety, memory and motor function

[4] N R Mirza, et al. NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile], a unique subtype-selective GABAA receptor positive allosteric modulator: in vitro actions, pharmacokinetic properties and in vivo anxiolytic efficacy

[5] G Munro, et al. Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with diazepam, zolpidem, bretazenil, and gaboxadol in rat models of inflammatory 䲧璵Ỵ璶㧀璴羹癦

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Keywords: NS11394 supplier, GABA Receptor, inhibitors, activators

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