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Baclofen

Cat. No. M5442
Baclofen Structure
Size Price Availability Quantity
50mg USD 45  USD50 In stock
100mg USD 54  USD60 In stock
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Quality Control
Biological Activity

Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 213.66
Formula C10H12ClNO2
CAS Number 1134-47-0
Purity 99.28%
Solubility 7.8 mg/mL in DMSO
Storage at -20°C
References

Baclofen overdose treated with continuous venovenous hemofiltration.
Meulendijks D, et al. Eur J Clin Pharmacol. 2015 Mar;71(3):357-61. PMID: 25567218.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Baclofen supplier, GABA Receptor, inhibitors

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