GABA Receptor GABA Receptor

Cat.No.	Name	Information
M2347	(+)-Bicuculline	(+)-Bicuculline is a competitive antagonist of GABA_A receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.
M5442	Baclofen	Baclofen is an orally active, selective metabotropic GABAB receptor (GABABR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research.
M5653	Flumazenil	Flumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses.
M4231	Ginkgolide-A	Ginkgolide A (BN-52020) is A GABA antagonist extracted from ginkgo biloba leaves.
M4073	Ginsenoside-Rc	Ginsenoside Rc is one of the major ginsenosides. Ginsenoside Rc enhances GABA receptor A (GABAA) -mediated ion channel (IGABA) currents. Ginsenoside Rc also inhibited TNF-α and IL-1β expression.
M4019	Songorine	Songorine is a diterpenoid alkaloid isolated from the genus Aconite. Songorine is a GABAA receptor antagonist in rat brain and has anticancer, anti-arrhythmia and anti-inflammatory activities. Songorine has potential to be used in epithelial ovarian cancer (EOC) studies.
M4013	Glabridin	Glabridin, one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory.
M3981	Bilobalide	Bilobalide, a natural product extracted from Ginkgo biloba leaf, is known to exhibit a number of pharmacological activities.
M3968	Dihydromyricetin	Dihydromyricetin is a natural antioxidant flavonoid from Ampelopsis grossedentata.
M3938	Baicalin	Baicalin is an allosteric carnitine palmityl transferase 1 (CPT1) activator. Baicalin reduces the expression of NF-κB.
M3600	Gabapentin	Gabapentin is a pharmaceutical agent, specifically a GABA analogue.
M3599	Pregabalin	Pregabalin (Lyrica) is a 3-isobutyl derivative of gamma-amino butyric acid (GABA) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities.
M3376	Chlormezanone	Chlormezanone，a non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm.
M3344	Nefiracetam	Nefiracetam is a GABAergic, cholinergic, and monoaminergic neuronal systems enhancer for Ro 5-4864-induced convulsions.
M2949	Piracetam	Piracetam is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders.
M2555	AWD 131-138	AWD 131-138 is a new low-affinity partial benzodiazepine receptor agonist with potent anticonvulsant and anxiolytic properties in rodent models.
M2439	Bemegride	Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning.
M2005	(R)-Baclofen	(R)-baclofen, a gamma-aminobutyric acid derivative and agonist at GABA-B receptors, inhibits nerve conduction in the central nervous system and can be used in studies related to spasticity.
M1954	Alpidem	Alpidem is a potent antagonist of peripheral benzodiazepine receptor (PBR).
M1891	SKF 89976A hydrochloride	SKF 89976A hydrochloride is a potent GABA uptake inhibitor, selective for GAT-1.
M56489	β-CCB	β-CCB is a ligand for benzodiazepine receptor, which inhibits the binding of [3H]flunitrazepam and ethyl (3-[3H]carboline-3-carboxylate to benzodiazepine receptors, with Ki of 3-4 nM.
M56488	TPMPA	TPMPA, a hybrid of isoguvacine and 3-APMPA, is the first selective antagonist for a GABAC receptor (KB = 2.1 μM), but not to interact with GABAA (KB = 320 μM) or GABAB receptors (EC50 = 500 μM).
M56487	CI-966	CI-966 is a potent, selective, orally active and brain-penetrant inhibitor of the GABA transporter GAT-1, with IC50s of 0.26 μM and 1.2 μM for hGAT-1, rGAT-1, respectively.

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GABA Receptor GABA Receptor

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