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Dihydromyricetin

Cat. No. M3968
Dihydromyricetin Structure
Synonym:

Ampeloptin,DMY,DHM

Size Price Availability Quantity
10mM*1mL in DMSO USD 45  USD50 In stock
5mg USD 45  USD50 In stock
10mg USD 64.8  USD72 In stock
50mg USD 99  USD110 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Dihydromyricetin (DHM), a natural flavonoid, exerts various bioactivities including anti-oxidative and hepatoprotective effects.Dihydromyricetin can protect HUVECs from oxidative stress damage, an effect that is mediated by the mitochondrial apoptotic pathways.Dihydromyricetin showed great antioxidative effect and would be a good natural antioxidant.Dihydromyricetin anti-alcohol effects on both behavior and CNS neurons were antagonized by flumazenil (10 mg/kg in vivo, 10 μM in vitro), the benzodiazepine (BZ) antagonist. Dihydromyricetin competitively inhibited BZ-site [3H]flunitrazepam binding (IC50, 4.36 μM), suggesting DHM interaction with EtOH involves the BZ-sites on GABAARs.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 320.25
Formula C15H12O8
CAS Number 27200-12-0
Purity >98%
Solubility DMSO 64mg/ml
Ethanol 64mg/ml
Storage at -20°C
References

Dihydromyricetin protects endothelial cells from hydrogen peroxide-induced oxidative stress damage by regulating mitochondrial pathways.
Hou X, et al. Life Sci. 2015 Mar 26. PMID: 25818185.

Effect of dihydromyricetin on benzo[a]pyrene activation in rats.
Hodek P, et al. Neuro Endocrinol Lett. 2014 Nov 30;35(Suppl 2):158-168. PMID: 25638381.

Antioxidation properties and mechanism of action of dihydromyricetin from Ampelopsis grossedentata.
Zhang YS, et al. Yao Xue Xue Bao. 2003 Apr;38(4):241-4. PMID: 12889119.

Dihydromyricetin As A Novel Anti-Alcohol Intoxication Medication.
Yi Shen, et al. J Neurosci. 2012 Jan 4;32(1): 390–401. PMID: 3292407.

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Keywords: Dihydromyricetin, Ampeloptin,DMY,DHM supplier, GABA Receptor, inhibitors

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