Bilobalide is a compound with neuroprotective, antibacterial, and inhibitory effects.Bilobalide inhibits the hypoxia-induced reduction of ATP and under normoxic conditions increase glucose transport.Bilobalide is a inhibitor of GABA Receptor and SR.Bilobalide induced P19 cells differentiation into neurons in a concentration- and time-dependent manner.Bilobalide promoted neuronal differentiation through activation of Wnt/β-catenin signaling pathway. Exposure to bilobalide increased inactive GSK-3β phosphorylation, further induced the nuclear accumulation of β-catenin, and also up-regulated the expression of Wnt ligands Wnt1 and Wnt7a.Bilobalide significantly protected adipocytes from adverse effects of hypoxia in a dose-dependent manner by attenuating oxidative stress, inflammation and protecting mitochondria.The neuroprotective effects of bilobalide on cerebral I/R injury are associated with its inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation.
Jiang M, et al. J Neuroinflammation. 2014 Sep 26;11:167. PMID: 25256700.
Bilobalide attenuates hypoxia induced oxidative stress, inflammation, and mitochondrial dysfunctions in 3T3-L1 adipocytes via its antioxidant potential.
Priyanka A, et al. Free Radic Res. 2014 Oct;48(10):1206-17. PMID: 25039303.
Bilobalide induces neuronal differentiation of P19 embryonic carcinoma cells via activating Wnt/β-catenin pathway.
Liu M, et al. Cell Mol Neurobiol. 2014 Aug;34(6):913-23. PMID: 24838256.
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