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Bilobalide

Cat. No. M3981
Bilobalide Structure
Synonym:

(-)-Bilobalide

Size Price Availability Quantity
10mM*1mL USD 58.5  USD65 In stock
10mg USD 45  USD50 In stock
50mg USD 162  USD180 In stock
100mg USD 216  USD240 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Bilobalide is a compound with neuroprotective, antibacterial, and inhibitory effects.Bilobalide inhibits the hypoxia-induced reduction of ATP and under normoxic conditions increase glucose transport.Bilobalide is a inhibitor of GABA Receptor and SR.Bilobalide induced P19 cells differentiation into neurons in a concentration- and time-dependent manner.Bilobalide promoted neuronal differentiation through activation of Wnt/β-catenin signaling pathway. Exposure to bilobalide increased inactive GSK-3β phosphorylation, further induced the nuclear accumulation of β-catenin, and also up-regulated the expression of Wnt ligands Wnt1 and Wnt7a.Bilobalide significantly protected adipocytes from adverse effects of hypoxia in a dose-dependent manner by attenuating oxidative stress, inflammation and protecting mitochondria.The neuroprotective effects of bilobalide on cerebral I/R injury are associated with its inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 326.30
Formula C15H18O8
CAS Number 33570-04-6
Purity >98%
Solubility Ethanol 25mg/ml
DMSO 25mg/ml
Storage at -20°C
References

Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation.
Jiang M, et al. J Neuroinflammation. 2014 Sep 26;11:167. PMID: 25256700.

Bilobalide attenuates hypoxia induced oxidative stress, inflammation, and mitochondrial dysfunctions in 3T3-L1 adipocytes via its antioxidant potential.
Priyanka A, et al. Free Radic Res. 2014 Oct;48(10):1206-17. PMID: 25039303.

Bilobalide induces neuronal differentiation of P19 embryonic carcinoma cells via activating Wnt/β-catenin pathway.
Liu M, et al. Cell Mol Neurobiol. 2014 Aug;34(6):913-23. PMID: 24838256.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Bilobalide, (-)-Bilobalide supplier, GABA Receptor, inhibitors

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