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Piracetam

Cat. No. M2949
Piracetam Structure
Size Price Availability Quantity
500mg USD 50  USD50 In stock
1g USD 62  USD62 In stock
5g USD 95  USD95 In stock
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Quality Control & Documentation
Biological Activity

Piracetam is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders.

Chemical Information
Molecular Weight 142.16
Formula C6H10N2O2
CAS Number 7491-74-9
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Pieter A Cohen, et al. Presence of Piracetam in Cognitive Enhancement Dietary Supplements

[2] Andrei G Malykh, et al. Piracetam and piracetam-like drugs: from basic science to novel clinical applications to CNS disorders

[3] Katarzyna Winnicka, et al. Piracetam--an old drug with novel properties?

[4] A H Gouliaev, et al. Piracetam and other structurally related nootropics

[5] M W Vernon, et al. Piracetam. An overview of its pharmacological properties and a review of its therapeutic use in senile cognitive disorders

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