| Cat.No. | Name | Information |
|---|---|---|
| M2347 | (+)-Bicuculline | (+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels. |
| M55450 | Pregabalin-d4 | Pregabalin-d4 |
| M45177 | 5-Aminovaleric acid | 5-Aminovaleric acid is a GABA receptor antagonist. |
| M45171 | L-2,4-Diaminobutyric acid dihydrochloride | L-2,4-Diaminobutyric acid dihydrochloride inhibits GABA transaminase activity, resulting in elevated GABA levels, and exhibits ex vivo antitumor activity against mouse fibrosarcoma cells. In addition, L-2,4-Diaminobutyric acid dihydrochloride can be used as an internal standard for amino acid analysis. |
| M42184 | γ-Acetylenic GABA hydrochloride | γ-Acetylenic GABA (GAG) hydrochloride is an irreversible inhibitor of GABA-transaminase. |
| M31393 | DL-Menthol | DL-Menthol is a cyclic monoterpene alcohol that is also associated with GABAA receptor activation and has local anesthetic activity. |
| M30609 | FG 7142 | FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex. |
| M29976 | Valerenic acid | Valerenic acid ((-)-Valerenic Acid), a sesquiterpenoid, is an orally active positive allosteric modulator of GABAA receptors. Valerenic acid is also a partial agonist of the 5-HT5a receptor. Valerenic acid mediates anxiolytic activity via GABAA receptors containing the β3 subunit. Valerenic acid also exhibits potent antioxidant properties. |
| M29494 | Fasedienol | Fasedienol is a neurochemical stimulator of the vomeronasal organ (VON). Fasedienol alleviates the symptoms of PMS and anxiety. |
| M28740 | Cipepofol | Cipepofol (HSK3486), a psychomotor stabilizing agent, is a gamma-aminobutyric acid (GABA) receptor potentiator. |
| M27944 | Broflanilide | Broflanilide is a potential insecticide and metabolized to Desmethyl-Broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin (RDL) GABA Receptor, and inhibits S. litura RDL GABAR, with an IC50 value of 1.3 nM. |
| M21509 | Afizagabar | Afizagabar (S44819) is a first-in-class, competitive and selective α5-GABAAR antagonist with an IC50 value of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. |
| M21364 | CNS 7056 | CNS 7056 is a short-acting GABAa receptor agonist used in general anesthesia. |
| M20438 | Phenibut | Phenibut, a GABA analogue, is a central nervous system depressant with anxiolytic and sedative effects. |
| M19287 | a-Asarone | alpha-Asarone (α-Asarone) is one of the main psychoactive compounds, and possesses an antidepressant-like activity in mice. |
| M19236 | Arecaidine | Arecaidine, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake. |
| M18259 | Arecaidine hydrochloride | Arecaidine hydrochloride |
| M14224 | Vigabatrin hydrochloride | Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. |
| M14221 | THIP | THIP (Gaboxadol) is a selective δ-aminobutyric acid type A receptor (δ-GABAAR) agonist, functionally selective GABAAR ligand, exhibits agonism at α4β1δ, α4β3δ and weak antagonism at αβγ and α4β2δ GABAARs. |
| M14219 | NS11394 | NS11394 is an orally active and unique subtype-selective GABAA positive allosteric receptor (PAM), with a Ki of ~0.5 nM. |
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