Free shipping on all orders over $ 500

Valerenic acid

Cat. No. M29976

All AbMole products are for research use only, cannot be used for human consumption.

Valerenic acid Structure
Synonym:

(-)-Valerenic Acid

Size Price Availability Quantity
1mg USD 110  USD110 In stock
5mg USD 290  USD290 In stock
10mg USD 460  USD460 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Valerenic acid ((-)-Valerenic Acid), a sesquiterpenoid, is an orally active positive allosteric modulator of GABAA receptors. Valerenic acid is also a partial agonist of the 5-HT5a receptor. Valerenic acid mediates anxiolytic activity via GABAA receptors containing the β3 subunit. Valerenic acid also exhibits potent antioxidant properties.

Chemical Information
Molecular Weight 234.33
Formula C15H22O2
CAS Number 3569-10-6
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jun Takahashi, et al. ACS Omega. Valerenic Acid Promotes Adipocyte Differentiation, Adiponectin Production, and Glucose Uptake via Its PPARγ Ligand Activity

[2] Mengya Zhao, et al. Biotechnol Lett. Biosynthesis of valerenic acid by engineered Saccharomyces cerevisiae

[3] Alfredo Rodríguez-Cruz, et al. IBRO Rep. "Effect of valerenic acid on neuroinflammation in a MPTP-induced mouse model of Parkinson's disease"

[4] Ekrem-Murat Gonulalan, et al. Saudi Pharm J. The roles of valerenic acid on BDNF expression in the SH-SY5Y cell

[5] No authors listed. Valerian

Related GABA Receptor Products
β-CCB 

β-CCB is a ligand for benzodiazepine receptor, which inhibits the binding of [3H]flunitrazepam and ethyl (3-[3H]carboline-3-carboxylate to benzodiazepine receptors, with Ki of 3-4 nM.

TPMPA 

TPMPA, a hybrid of isoguvacine and 3-APMPA, is the first selective antagonist for a GABAC receptor (KB = 2.1 μM), but not to interact with GABAA (KB = 320 μM) or GABAB receptors (EC50 = 500 μM).

CI-966 

CI-966 is a potent, selective, orally active and brain-penetrant inhibitor of the GABA transporter GAT-1, with IC50s of 0.26 μM and 1.2 μM for hGAT-1, rGAT-1, respectively.

NCS-382 

NCS-382 is a potent GABA receptor antagonist and also a GHBR receptor antagonist.

CGS 8216 

CGS 8216, a benzodiazepine receptor antagonist, inhibits 3H-flunitrazepam (3H-FLU) binding to rat synaptosomal membranes in vitro at subnanomolar concentrations.

  Catalog
Abmole Inhibitor Catalog




Keywords: Valerenic acid, (-)-Valerenic Acid supplier, GABA Receptor, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.