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Fasedienol

Cat. No. M29494
Fasedienol Structure
Synonym:

PH94B

Size Price Availability Quantity
5mg USD 235  USD235 In stock
10mg USD 380  USD380 In stock
25mg USD 760  USD760 In stock
50mg USD 1200  USD1200 In stock
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Quality Control & Documentation
Biological Activity

Fasedienol is a neurochemical stimulator of the vomeronasal organ (VON). Fasedienol alleviates the symptoms of PMS and anxiety.

Chemical Information
Molecular Weight 272.43
Formula C19H28O
CAS Number 23062-06-8
Form Solid
Solubility (25°C) DMSO 25 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] N S H N Moorthy, et al. Curr Med Chem. Farnesyltransferase inhibitors: a comprehensive review based on quantitative structural analysis

[2] Karsten Krohn, et al. Chemistry. Xanthones and oxepino[2, 3-b]chromones from three endophytic fungi

[3] Young-sil Ha, et al. FEMS Microbiol Lett. Functional analysis of Ras in Colletotrichum trifolii

[4] Sheo B. Singh, et al. J Org Chem. Fusidienol A: A Novel Ras Farnesyl-Protein Transferase Inhibitor from Phoma sp

[5] L V Roze, et al. Fungal Genet Biol. Evidence that MRas1 and MRas3 proteins are associated with distinct cellular functions during growth and morphogenesis in the fungus Mucor racemosus

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Keywords: Fasedienol, PH94B supplier, GABA Receptor, inhibitors, activators


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