| Cat.No. | Name | Information |
|---|---|---|
| M2347 | (+)-Bicuculline | (+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels. |
| M5442 | Baclofen | Baclofen is an orally active, selective metabotropic GABAB receptor (GABABR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research. |
| M5653 | Flumazenil | Flumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses. |
| M7607 | 5α-Androst-16-en-3α-ol | 5alpha-androst-16-en-3alp |
| M7442 | U 93631 | U 93631 is a gABA A receptor antagonist. |
| M7410 | THIP hydrochloride | THIP hydrochloride (Gaboxadol hydrochloride) is a potent agonist of the GABAA receptor and an antagonist of GABAC receptors (IC50=25 μM). Gaboxadol hydrochloride displays a partial agonist efficacy on subunit α1β2γ2 with an ED50 value of 143 µM, a full agonist efficacy at α5 subunit (ED50=28-129 µM) and a superagonist efficacy at α4β3δ (ED50=6 µM). |
| M7252 | SB 205384 | SB 205384 is a gABA A receptor modulator; slows current decay. |
| M7242 | Saclofen | Saclofen is a selective GABA B antagonist. |
| M6744 | Ganaxolone | Ganaxolone (CCD 1042) is A neuroactive steroid allopregnenolone analogue synthesized orally and is A selective, high-affinity positive sex modulator of γ -aminobutyrate-A (GABAA) receptor with anticonvulsant properties. Gannadone works through different binding sites with benzodiazepine binding sites and can be used in epilepsy studies related to cyclin-dependent kinase-like 5 (CDKL5) deficiency (CDD). |
| M6585 | CGP52432 | CGP 52432 is a potent, selective GABAB antagonist. |
| M6319 | 17-PA | 17-PA is a antagonist of neurosteroid potentiation and direct gating of GABA A. |
| M6245 | Basmisanil | Basmisanil is a highly selective GABAAα5 negative allosteric modulator. |
| M6195 | Propofol | Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties. |
| M6010 | Tiagabine HCl | Tiagabine Hydrochloride is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor. |
| M5870 | Pentylenetetrazol | Pentylenetetrazol displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GABA(A) receptor antagonist. |
| M5730 | L-Cycloserine | L-cycloserine irreversibly inhibit GABA pyridoxal 5′-phosphate-dependent aminitransferase in E. coli, as well in the brains of various animals in a time-dependent manner, results in increased levels of gamma-aminobutyric acid (GABA), which is an inhibitory neurotransmitter in vivo. |
| M5669 | Gabapentin HCl | Gabapentin HCl is a GABA analogue, used to treat seizures and neuropathic pain. |
| M5575 | Dihydroergotoxine mesylate | Dihydroergotoxine mesylate is a complex of closely related alkaloid salts; Binds with high affinity to the GABAA receptor Cl- channel, producing an allosteric interaction with the benzodiazepine site. |
| M5390 | Afloqualone | Afloqualone is a agonist of GABA receptor . |
| M5378 | Acamprosate calcium | Acamprosate calcium (Campral EC) is a GABA receptor agonist and glutamate system modulator. |
| M5172 | 6-Prenylnaringenin | (2S)-6-Prenylnaringenin acts as a GABAA positive allosteric modulator at α+β- binding interface. |
| M4815 | Vigabatrin | Vigabatrin (γ-Vinyl-GABA), an inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. |
| M4441 | Jujuboside-A | Jujuboside A is A glycoside extracted from the Chinese traditional medicine ziziphus jujuboides, which can be used in studies on insomnia and anxiety symptoms. |
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