| Cat.No. | Name | Information |
|---|---|---|
| M2347 | (+)-Bicuculline | (+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels. |
| M7410 | THIP hydrochloride | THIP hydrochloride (Gaboxadol hydrochloride) is a potent agonist of the GABAA receptor and an antagonist of GABAC receptors (IC50=25 μM). Gaboxadol hydrochloride displays a partial agonist efficacy on subunit α1β2γ2 with an ED50 value of 143 µM, a full agonist efficacy at α5 subunit (ED50=28-129 µM) and a superagonist efficacy at α4β3δ (ED50=6 µM). |
| M7252 | SB 205384 | SB 205384 is a gABA A receptor modulator; slows current decay. |
| M7242 | Saclofen | Saclofen is a selective GABA B antagonist. |
| M6744 | Ganaxolone | Ganaxolone (CCD 1042) is A neuroactive steroid allopregnenolone analogue synthesized orally and is A selective, high-affinity positive sex modulator of γ -aminobutyrate-A (GABAA) receptor with anticonvulsant properties. Gannadone works through different binding sites with benzodiazepine binding sites and can be used in epilepsy studies related to cyclin-dependent kinase-like 5 (CDKL5) deficiency (CDD). |
| M6585 | CGP52432 | CGP 52432 is a potent, selective GABAB antagonist. |
| M6319 | 17-PA | 17-PA is a antagonist of neurosteroid potentiation and direct gating of GABA A. |
| M6245 | Basmisanil | Basmisanil is a highly selective GABAAα5 negative allosteric modulator. |
| M6195 | Propofol | Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties. |
| M6010 | Tiagabine HCl | Tiagabine Hydrochloride is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor. |
| M5870 | Pentylenetetrazol | Pentylenetetrazol displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GABA(A) receptor antagonist. |
| M5730 | L-Cycloserine | L-cycloserine irreversibly inhibit GABA pyridoxal 5′-phosphate-dependent aminitransferase in E. coli, as well in the brains of various animals in a time-dependent manner, results in increased levels of gamma-aminobutyric acid (GABA), which is an inhibitory neurotransmitter in vivo. |
| M5669 | Gabapentin HCl | Gabapentin HCl is a GABA analogue, used to treat seizures and neuropathic pain. |
| M5653 | Flumazenil | Flumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses. |
| M5575 | Dihydroergotoxine mesylate | Dihydroergotoxine mesylate is a complex of closely related alkaloid salts; Binds with high affinity to the GABAA receptor Cl- channel, producing an allosteric interaction with the benzodiazepine site. |
| M5442 | Baclofen | Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant. |
| M5390 | Afloqualone | Afloqualone is a agonist of GABA receptor . |
| M5378 | Acamprosate calcium | Acamprosate calcium (Campral EC) is a GABA receptor agonist and glutamate system modulator. |
| M5172 | 6-Prenylnaringenin | (2S)-6-Prenylnaringenin acts as a GABAA positive allosteric modulator at α+β- binding interface. |
| M4815 | Vigabatrin | Vigabatrin (γ-Vinyl-GABA), an inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. |
| M4441 | Jujuboside-A | Jujuboside A is A glycoside extracted from the Chinese traditional medicine ziziphus jujuboides, which can be used in studies on insomnia and anxiety symptoms. |
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