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Dihydroergotoxine mesylate

Cat. No. M5575
Dihydroergotoxine mesylate Structure
Synonym:

Ergoloid mesylates

Size Price Availability Quantity
100mg USD 108  USD120 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Dihydroergotoxine mesylate is a complex of closely related alkaloid salts; Binds with high affinity to the GABAA receptor Cl- channel, producing an allosteric interaction with the benzodiazepine site.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 2314.74
Formula C123H156N20O23S
CAS Number 8067-24-1
Purity >98%
Solubility 31 mg/mL in DMSO
Storage at -20°C
References

Identification and human pharmacokinetics of dihydroergotoxine metabolites in man: preliminary results.
Bicalho B, et al. Biopharm Drug Dispos. 2008 Jan;29(1):17-28. PMID: 17941060.

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Keywords: Dihydroergotoxine mesylate, Ergoloid mesylates supplier, GABA Receptor, inhibitors

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