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CGP52432

Cat. No. M6585

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CGP52432 Structure
Synonym:

CGP-52432

Size Price Availability Quantity
5mg USD 90  USD90 In stock
10mg USD 160  USD160 In stock
25mg USD 350  USD350 In stock
50mg USD 630  USD630 In stock
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Quality Control & Documentation
Biological Activity

CGP 52432 is a potent, selective GABAB receptor antagonist (IC50 = 85 nM). CGP52432 (10, 30 mg/kg) shows no effect on the total arm entries and total head dips of mice on the elevated-plus maze. CGP52432 (100 nmol/kg, i.v., or 1 nmol/kg, i.c.v.) abolishes the suppressive effects of GABA ( 50 μmol/kg, i.v.) on enhanced renal sympathetic nerve activity (RSNA) during ischaemia, causeing elimination of the renoprotective effects of GABA in rats.

Chemical Information
Molecular Weight 384.24
Formula C15H24Cl2NO4P
CAS Number 139667-74-6
Solubility (25°C) DMSO 4 mg/mL
Water 2 mg/mL (with sonication)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jagtap, et al. Bioorg Med Chem Lett. The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1).

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  Catalog
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Keywords: CGP52432, CGP-52432 supplier, GABA Receptor, inhibitors, activators

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