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Pentylenetetrazol

Cat. No. M5870
Pentylenetetrazol Structure
Synonym:

Pentylenetetrazole, Metrazole, pentetrazol

Size Price Availability Quantity
100mg USD 45  USD50 In stock
500mg USD 81  USD90 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Pentylenetetrazol displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GABA(A) receptor antagonist.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 138.17
Formula C6H10N4
CAS Number 54-95-5
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

The chemical induction of seizures in psychiatric therapy: were flurothyl (indoklon) and pentylenetetrazol (metrazol) abandoned prematurely?
Cooper K, et al. J Clin Psychopharmacol. 2014 Oct;34(5):602-7. PMID: 25029329.

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  Catalog
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Keywords: Pentylenetetrazol, Pentylenetetrazole, Metrazole, pentetrazol supplier, GABA Receptor, inhibitors

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