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Pentylenetetrazol

Cat. No. M5870
Pentylenetetrazol Structure
Synonym:

Pentylenetetrazole, Metrazole, pentetrazol

Size Price Availability Quantity
100mg USD 50  USD50 In stock
500mg USD 90  USD90 In stock
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Quality Control & Documentation
Biological Activity

Pentylenetetrazol displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GABA(A) receptor antagonist.

Chemical Information
Molecular Weight 138.17
Formula C6H10N4
CAS Number 54-95-5
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Cooper K, et al. J Clin Psychopharmacol. The chemical induction of seizures in psychiatric therapy: were flurothyl (indoklon) and pentylenetetrazol (metrazol) abandoned prematurely?

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Keywords: Pentylenetetrazol, Pentylenetetrazole, Metrazole, pentetrazol supplier, GABA Receptor, inhibitors, activators


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