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L-Cycloserine

Cat. No. M5730
L-Cycloserine Structure
Synonym:

(S)-4-Amino-3-isoxazolidone; (S)-Cycloserine

Size Price Availability Quantity
10mg USD 54  USD60 In stock
50mg USD 72  USD80 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

L-cycloserine irreversibly inhibit GABA pyridoxal 5′-phosphate-dependent aminitransferase in E. coli, as well in the brains of various animals in a time-dependent manner, results in increased levels of gamma-aminobutyric acid (GABA), which is an inhibitory neurotransmitter in vivo.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 102.09
Formula C3H6N2O2
CAS Number 339-72-0
Purity >98%
Solubility 36 mg/mL in water
Storage at -20°C
References

Exposure to L-cycloserine incurs survival costs and behavioral alterations in Aedes aegypti females.
Belloni V, et al. Parasit Vectors. 2014 Aug 16;7:373. PMID: 25129074.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: L-Cycloserine, (S)-4-Amino-3-isoxazolidone; (S)-Cycloserine supplier, GABA Receptor, inhibitors

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