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Propofol inhibited tumor size, cell viability and promoted cell apoptosis via inhibiting mTOR/p70S6K pathway mediated by HOTAIR in cervical cancer. In present study, we found propofol markedly decreased the HOTAIR expression of cervical cancer cells in a dose-dependent manner. In vitro experiments, we found HOTAIR overexpression promoted cervical carcinoma cells growth and inhibited cell apoptosis after the treatment of propofol.
Cell Experiment | |
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Cell lines | Caski cells |
Preparation method | 1 × 10^4 cells/well HeLa, CaSki and C33A cells were plated incubated in 96-well culture plates at 37℃ for 24 h, and then co-cultured with different concentrations (0 μg/ml, 1 μg/ml, 5 μg/ml and 10 μg/ml) of propofol for another 48 h. |
Concentrations | 10 μg/ml |
Incubation time | 48 h |
Animal Experiment | |
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Animal models | C57BL/6 mice |
Formulation | soybean oil |
Dosages | 50 mg/kg |
Administration | i.p. |
Molecular Weight | 178.27 |
Formula | C12H18O |
CAS Number | 2078-54-8 |
Form | Melting point 18°C |
Solubility (25°C) | DMSO ≥ 60 mg/mL |
Storage | 2-8°C, sealed |
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