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U 93631 is a gABAA receptor antagonist that binds the picrotoxin site and stabilizes the inactive form of the channel via allosteric interaction. Accelerates the decay of GABA-induced Cl- currents with little effect on peak amplitude. Also inhibits 5-HT3A receptors via a similar mechanism.
| Molecular Weight | 299.37 |
| Formula | C17H21N3O2 |
| CAS Number | 152273-12-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 29.94 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related GABA Receptor Products |
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| TPMPA
TPMPA, a hybrid of isoguvacine and 3-APMPA, is the first selective antagonist for a GABAC receptor (KB = 2.1 μM), but not to interact with GABAA (KB = 320 μM) or GABAB receptors (EC50 = 500 μM). |
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| NCS-382
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| CGS 8216
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