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Flumazenil

Cat. No. M5653
Flumazenil Structure
Synonym:

Ro 15-1788

Size Price Availability Quantity
50mg USD 108  USD120 In stock
100mg USD 162  USD180 In stock
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Quality Control
Biological Activity

Flumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 303.29
Formula C15H14FN3O3
CAS Number 78755-81-4
Purity 99.51%
Solubility 10 mM in DMSO
Storage at -20°C
References

Benzodiazepine dependence and its treatment with low dose flumazenil.
Hood SD, et al. Br J Clin Pharmacol. 2014 Feb;77(2):285-94. PMID: 23126253.

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Abmole Inhibitor Catalog 2017




Keywords: Flumazenil, Ro 15-1788 supplier, GABA Receptor, inhibitors

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