Free shipping on all orders over $ 500

Flumazenil

Cat. No. M5653
Flumazenil Structure
Synonym:

Ro 15-1788

Size Price Availability Quantity
50mg USD 120  USD120 In stock
100mg USD 180  USD180 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Flumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses.

Chemical Information
Molecular Weight 303.29
Formula C15H14FN3O3
CAS Number 78755-81-4
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hood SD, et al. Br J Clin Pharmacol. Benzodiazepine dependence and its treatment with low dose flumazenil.

Related GABA Receptor Products
Cenobamate

Cenobamate (YKP-3089) is a novel antiepileptic agent with broad-spectrum anticonvulsant activity.

Afizagabar

Afizagabar (S44819) is a first-in-class, competitive and selective α5-GABAAR antagonist with an IC50 value of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2.

Pentetrazol (98%)

Pentetrazol (PTZ), a tetrazole derivative, is an inhibitor of gamma aminobutyric acid (GABAA) and its receptor complex. PTZ is a convulsive agent used to induce convulsions. It can penetrate the blood-brain barrier.

L-DAB HBR

L-DAB HBR (L-Dab Hydrobromide, L-2,4-Diaminobutyric acid hydrobromide) is an inhibitor of GABA (Gamma-aminobutyric acid) transaminase with IC50 of >500 μM. L-DAB HBR exhibits antitumor activity.

Phenibut

Phenibut, a GABA analogue, is a central nervous system depressant with anxiolytic and sedative effects.

  Catalog
Abmole Inhibitor Catalog




Keywords: Flumazenil, Ro 15-1788 supplier, GABA Receptor, inhibitors, activators

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.