Baicalin facilitated the transfer of electrons from Fe (2+) to dissolved oxygen.Baicalin has the capacity to protect IEC-6 cells and the intercellular tight junctions from LPS-induced injury.The mechanisms may be associated with inhibiting the production of inflammatory cytokines,and up-regulating the mRNA and protein expression of ZO-1.baicalin had no effects on the pharmacokinetics of caffeine and its metabolites in vivo,following single oral administration in rats.Anti-inflammatory properties of baicalin may be resulted from the inhibition of IL-6, IL-8, and TNF-α expression via preventing signaling NF-κB pathway in HBE16 airway epithelial cells.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
Effects of baicalin on oral pharmacokinetics of caffeine in rats.
Noh K, et al. Biomol Ther (Seoul). 2015 Mar;23(2):201-6. PMID: 25767690.
Protective effects of baicalin on LPS-induced injury in intestinal epithelial cells and intercellular tight junctions.
Chen J, et al. Can J Physiol Pharmacol. 2015 Apr;93(4):233-7. PMID: 25665915.
Baicalin inhibits the fenton reaction by enhancing electron transfer from fe (2+) to dissolved oxygen.
Nishizaki D, et al. Am J Chin Med. 2015;43(1):87-101. PMID: 25640849.
Baicalin Inhibits Lipopolysaccharide-Induced Inflammation Through Signaling NF-κB Pathway in HBE16 Airway Epithelial Cells.
Dong SJ, et al. Inflammation. 2015 Jan 30. PMID: 25630720.
|Related GABA Receptor Products|
Zuranolone also known as SAGE-217, is a potent GABAA receptor agonist with EC50 values of 296 nM and 163 nM for α1β2γ2 and α4β3δ GABAA receptors.
SSD114 hydrochloride is a GABAB receptor positive allosteric modulator.
Pipequaline (PK-8165) is a partial benzodiazepine receptor agonist with anxiolytic activity.
AZD-7325 is a GABA-Aα2,3 -selective receptor modulator.
ONO-8590580 is a GABAAα5 negative allosteric modulator which enhances long-term potentiation and improves cognitive deficits in preclinical models.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.