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Baicalin

Cat. No. M3938
Baicalin Structure
Synonym:

Baicalein 7-O-β-D-glucuronide

Size Price Availability Quantity
10mM*1mL in DMSO USD 63  USD70 In stock
10mg USD 54  USD60 In stock
50mg USD 81  USD90 In stock
100mg USD 108  USD120 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Baicalin facilitated the transfer of electrons from Fe (2+) to dissolved oxygen.Baicalin has the capacity to protect IEC-6 cells and the intercellular tight junctions from LPS-induced injury.The mechanisms may be associated with inhibiting the production of inflammatory cytokines,and up-regulating the mRNA and protein expression of ZO-1.baicalin had no effects on the pharmacokinetics of caffeine and its metabolites in vivo,following single oral administration in rats.Anti-inflammatory properties of baicalin may be resulted from the inhibition of IL-6, IL-8, and TNF-α expression via preventing signaling NF-κB pathway in HBE16 airway epithelial cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 446.36
Formula C21H18O11
CAS Number 21967-41-9
Purity >98%
Solubility DMSO
Storage at -20°C
References

Effects of baicalin on oral pharmacokinetics of caffeine in rats.
Noh K, et al. Biomol Ther (Seoul). 2015 Mar;23(2):201-6. PMID: 25767690.

Protective effects of baicalin on LPS-induced injury in intestinal epithelial cells and intercellular tight junctions.
Chen J, et al. Can J Physiol Pharmacol. 2015 Apr;93(4):233-7. PMID: 25665915.

Baicalin inhibits the fenton reaction by enhancing electron transfer from fe (2+) to dissolved oxygen.
Nishizaki D, et al. Am J Chin Med. 2015;43(1):87-101. PMID: 25640849.

Baicalin Inhibits Lipopolysaccharide-Induced Inflammation Through Signaling NF-κB Pathway in HBE16 Airway Epithelial Cells.
Dong SJ, et al. Inflammation. 2015 Jan 30. PMID: 25630720.

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Keywords: Baicalin, Baicalein 7-O-β-D-glucuronide supplier, GABA Receptor, inhibitors

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