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SSD114 hydrochloride

Cat. No. M9874
SSD114 hydrochloride Structure
Synonym:

SSD114 HCl

Size Price Availability Quantity
5mg USD 108  USD120 In stock
10mg USD 162  USD180 In stock
25mg USD 270  USD300 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

SSD114 hydrochloride is a GABAB receptor positive allosteric modulator.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 387.83
Formula C18H21ClF3N3O
CAS Number 2319790-02-6
Purity >99%
Solubility DMSO ≥ 90 mg/mL
Storage at -20°C
References

In vitro and in vivo pharmacological characterization of SSD114, a novel GABAB positive allosteric modulator
Alessandra Porcu, et al. Eur J Pharmacol. 2016 Nov 15;791:115-123. PMID: 27578262.

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  Catalog
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