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Pipequaline

Cat. No. M9856
Pipequaline Structure
Synonym:

PK-8165

Size Price Availability Quantity
10mg USD 90  USD100 In stock
50mg USD 315  USD350 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Pipequaline (PK-8165) is a partial benzodiazepine receptor agonist with anxiolytic activity. Pipequaline acts as a non-selective GABAA receptor partial agonist. Pipequaline produces dose-related decreases in motor activity. Pipequaline produces significant dose-related decreases in the number of head-dips made.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 316.44
Formula C22H24N2
CAS Number 77472-98-1
Purity >99%
Solubility DMSO 28 mg/mL
Storage at -20°C
References

The effects on memory of pipequaline, alone or in combination with diazepam
F F Eves, et al. Psychopharmacology (Berl). 1988;95(3):386-9. PMID: 3137626.

Effects of PK 8165, a partial benzodiazepine receptor agonist, on cholecystokinin-induced activation of hippocampal pyramidal neurons: a microiontophoretic study in the rat
J Bradwejn, et al. Eur J Pharmacol. 1985 Jun 19;112(3):415-8. PMID: 2990972.

Pipequaline acts as a partial agonist of benzodiazepine receptors: an electrophysiological study in the hippocampus of the rat
G Debonnel, et al. Neuropharmacology. 1987 Sep;26(9):1337-42. PMID: 2823163.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Pipequaline, PK-8165 supplier, GABA Receptor, inhibitors

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