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5α-Androst-16-en-3α-ol

Cat. No. M7607
5α-Androst-16-en-3α-ol Structure
Size Price Availability Quantity
25mg USD 200  USD200 In stock
50mg USD 350  USD350 In stock
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Quality Control & Documentation
Biological Activity

5alpha-androst-16-en-3alpha-ol (androstenol), is an androgen believed to act as a pheromone.

Chemical Information
Molecular Weight 274.44
Formula C19H30O
CAS Number 1153-51-1
Solubility (25°C) Ethanol 19 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Christian Starkenmann, et al. 5α-Androst-16-en-3α-ol β-D-glucuronide, precursor of 5α-androst-16-en-3α-ol in human sweat

[2] Guan Wang, et al. Determination of 5alpha-androst-16-en-3alpha-ol in truffle fermentation broth by solid-phase extraction coupled with gas chromatography-flame ionization detector/electron impact mass spectrometry

[3] K Shinohara, et al. Effects of 5alpha-androst-16-en-3alpha-ol on the pulsatile secretion of luteinizing hormone in human females

[4] M Morofushi, et al. Positive relationship between menstrual synchrony and ability to smell 5alpha-androst-16-en-3alpha-ol

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