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LAU159

Cat. No. M9114
LAU159 Structure
Synonym:

LAU-159

Size Price Availability Quantity
2mg USD 180  USD200 In stock
5mg USD 243  USD270 In stock
10mg USD 360  USD400 In stock
25mg USD 612  USD680 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

LAU159 is a potent, functionally selective α6β3γ2 GABAA receptor modulator.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 325.75
Formula C17H12ClN3O2
CAS Number 2055050-87-6
Purity >98%
Solubility DMSO 10 mM
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: LAU159, LAU-159 supplier, GABA Receptor, inhibitors

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