Free shipping on all orders over $ 500

LAU159

Cat. No. M9114
LAU159 Structure
Synonym:

LAU-159

Size Price Availability Quantity
2mg USD 200  USD200 In stock
5mg USD 270  USD270 In stock
10mg USD 400  USD400 In stock
25mg USD 680  USD680 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

LAU159 is a potent, functionally selective α6β3γ2 GABAA receptor modulator.

Chemical Information
Molecular Weight 325.75
Formula C17H12ClN3O2
CAS Number 2055050-87-6
Solubility (25°C) DMSO 10 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Related GABA Receptor Products
CGP7930

CGP7930 (3-(3’,5’-Di-tert-butyl-4’-hydroxy) phenyl-2, 2-dimethylpropanol) is a positive metabotropic GABAB receptor allosteric modulator.

5-Aminovaleric acid

5-Aminovaleric acid is a GABA receptor antagonist.

L-2,4-Diaminobutyric acid dihydrochloride

L-2,4-Diaminobutyric acid dihydrochloride inhibits GABA transaminase activity, resulting in elevated GABA levels, and exhibits ex vivo antitumor activity against mouse fibrosarcoma cells. In addition, L-2,4-Diaminobutyric acid dihydrochloride can be used as an internal standard for amino acid analysis.

3,4,5-Trimethoxy-trans-cinnamic acid

(E)-3,4,5-Trimethoxycinnamic acid (TMCA) is a cinnamic acid substituted by multi-methoxy groups.

NCS-382 sodium

NCS-382 (sodium) is a potent GABA receptor antagonist.

  Catalog
Abmole Inhibitor Catalog




Keywords: LAU159, LAU-159 supplier, GABA Receptor, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.