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Delafloxacin is a fluoroquinolone antibiotic active against both Gram-negative and Gram-positive bacteria such as MRSA. Delafloxacin targets both DNA gyrase and topoisomerase IV, inhibiting DNA synthesis. Unlike most fluoroquinolones, delafloxacin is weakly acidic, which increases its potency in an acidic environments such as those existing in inflammatory cells and in skin and soft tissue infections. Delafloxacin shows good activity against most fluoroquinolone-resistant strains.
| Molecular Weight | 440.76 |
| Formula | C18H12ClF3N4O4 |
| CAS Number | 189279-58-1 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] L J Scott. Delafloxacin: A Review in Acute Bacterial Skin and Skin Structure Infections
[3] No authors listed. Delafloxacin
[4] Jennifer Shiu, et al. Clinical Pharmacokinetics and Pharmacodynamics of Delafloxacin
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