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BODIPY 493/503

Cat. No. M9850
BODIPY 493/503 Structure
Size Price Availability Quantity
5mg USD 32  USD32 In stock
10mg USD 50  USD50 In stock
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Biological Activity

BODIPY 493/503 is a lipophilic fluorescent probe that localizes to polar lipids and can be used to label cellular neutral lipid contents, particularly those localized to lipid droplets, in live and fixed cells. It displays excitation/emission maxima of 493/503 nm, respectively.

Product Citations
Chemical Information
Molecular Weight 262.11
Formula C14H17BF2N2
CAS Number 121207-31-6
Solubility (25°C) DMSO
Ethanol
Storage -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Laura Cristina Ceafalan, et al. J Cell Mol Med. Age-related ultrastructural changes of the basement membrane in the mouse blood-brain barrier

[2] Bo Qiu, et al. Bio Protoc. BODIPY 493/503 Staining of Neutral Lipid Droplets for Microscopy and Quantification by Flow Cytometry

[3] Laura L Listenberger, et al. Curr Protoc Cell Biol. Fluorescent Detection of Lipid Droplets and Associated Proteins

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