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Galidesivir (BCX4430) hydrochloride, an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity. Galidesivir hydrochloride is active in vitro against many RNA viral pathogens, including the filoviruses and emerging infectious agents such as MERS-CoV, SARS-CoV, and SARS-CoV-2. Galidesivir hydrochloride inhibits some negative-sense RNA viruses with EC50s ranging from ~3 to ~68 μM.
| Molecular Weight | 301.73 |
| Formula | C11H16ClN5O3 |
| CAS Number | 222631-44-9 |
| Form | Solid |
| Solubility (25°C) | DMSO 105 mg/mL (ultrasonic) Water ≥ 41 mg/mL |
| Storage | 4°C, dry, sealed |
[2] Elena Bekerman, et al. Science. Infectious disease. Combating emerging viral threats
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