| Cat.No. | Name | Information |
|---|---|---|
| M4879 | Cycloheximide | Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5 nM. |
| M2129 | Temozolomide | Temozolomide (TMZ) is an oral DNA methylating, chemotherapeutic agent. |
| M2223 | Cisplatin | Cisplatin is an inorganic platinum complex that inhibits DNA synthesis by forming DNA crosslinking agents, inactivates GPXs, reduces cell GSH and induces iron death in HCT116 and A549 cells. |
| M2289 | 5-fluorouracil | 5-fluorouracil (5-FU) is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. |
| M2288 | Carboplatin | Carboplatin (NSC 241240) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism. |
| M2292 | Cytarabine | Cytarabine (Cytosine arabinoside, AraC) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM. |
| M1716 | Gemcitabine Hydrochloride | Gemcitabine (Gemzar, LY188011) inhibits DNA synthesis with an IC50 of 0.06 µM. |
| M5680 | Gemcitabine | Gemcitabine(LY-188011; NSC 613327) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. |
| M5277 | B02 | B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM). |
| M7515 | Brivudine | Brivudine is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication. |
| M7506 | 5-methoxyflavone | 5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. |
| M6528 | BRACO-19 trihydrochloride | BRACO-19 trihydrochloride is a potent telomerase/telomere inhibitor, preventing the capping and catalytic action of telomerase. Braco-19 acts as G-quadruplex (GQ) binding ligand, stabilizing G-quadruplexes formation at the 3V telomeric DNA overhang and produce rapid senescence or selective cell death. |
| M6449 | Aphidicolin | Aphidicolin is a DNA polymerase α, δ and ε inhibitor. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola, inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. |
| M6332 | 3-AP | 3-AP is a ribonucleotide reductase inhibitor; also an iron chelator. |
| M6306 | Madrasin | Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. |
| M6264 | Favipiravir | Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections. |
| M6053 | Vidarabine | Vidarabine is effective against herpes simplex virus and varicella-zoster virus. |
| M6046 | Uridine | Uridine is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond. |
| M5930 | Rifampicin | Rifampin is a DNA-dependent RNA polymerase inhibitor, it is also a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities. |
| M5836 | Orotic acid (6-Carboxyuracil) | Orotic acid(6-Carboxyuracil) is a heterocyclic compound and an acid. |
| M5771 | Mercaptopurine (6-MP) | Mercaptopurine (6-MP) inhibits neopurine synthesis by incorporating methyltransferase metabolites of Mercaptopurine into DNA and RNA. |
| M5767 | Menadione (Vitamin K3) | Menadione(Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement. |
| M5651 | Flucytosine | Flucytosine (5-Fluorocytosine, 5-FC, Ancobon), a fluorinated pyrimidine analogue, is an antifungal drug. |
| M5648 | Floxuridine | Floxuridine (5-fluorouracil 2'-deoxyriboside) is a pyrimidine analogue that is also an antitumor metabolite of oncology. Floxuridine inhibits the Poly(ADP-Ribose) polymerase and induces DNA damage in vitro by activating ATM and ATR checkpoint signaling pathways. Floxuridine is an effective inhibitor of Staphylococcus aureus infection and can induce apoptosis. Floxuridine is resistant to HSV and CMV viruses. |
| M5585 | Dithranol | Dithranol (Anthralin) can be used in psoriasis studies to inhibit DNA replication and repair. |
| M5545 | Cytidine | Cytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring, cytidine is a component of RNA. |
| M5526 | Clevudine | Clevudine (L-FMAU) is a nucleoside analogue with unnatural L-configuration, which has strong anti-HBV activity, long half-life and low toxicity. Clevudine is a non-competitive inhibitor that binds not to viral DNA but to the polymerase. |
| M5375 | 6-Mercaptopurine (6-MP) Monohydrate | Mercaptopurine inhibits purine nucleotide synthesis and metabolism by inhibiting phosphoribose pyrophosphate amide transferase (PRPP amide transferase). PRPP amide transferase is a rate-limiting enzyme formed by purine. It alters the synthesis and function of RNA and DNA. Mercaptopurine also interferes with nucleoside tautomies and glycoprotein synthesis. |
| M5300 | Deoxycytidine triphosphate | Deoxycytidine triphosphate (dCTP), a nucleoside triphosphate, is a raw material in DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing. |
| M5124 | Mupirocin | Mupirocin is a RNA Synthetase Inhibitor Antibacterial. The mechanism of action of mupirocin is as a RNA Synthetase Inhibitor. |
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