DNA/RNA Synthesis DNA/RNA Synthesis

Cat.No.	Name	Information
M4879	Cycloheximide	Cycloheximide (Naramycin A) is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5 nM. Cycloheximide binds to the E-site of the 60S subunit of the ribosome during the protein synthesis process in eukaryotic cells, blocking the ribosome translocation process mediated by eEF2 and preventing the synthesis of new proteins. Cycloheximide suppresses ferroptosis and inhibits autophagy.
M2129	Temozolomide	Temozolomide (TMZ) is an oral DNA methylating, chemotherapeutic agent.
M2223	Cisplatin	Cisplatin is an inorganic platinum complex that inhibits DNA synthesis by forming DNA crosslinking agents, inactivates GPXs, reduces cell GSH and induces iron death in HCT116 and A549 cells.
M2289	5-Fluorouracil	5-Fluorouracil (5-FU) is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools.
M2288	Carboplatin	Carboplatin (NSC 241240) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism.
M2292	Cytarabine	Cytarabine (Cytosine arabinoside, AraC) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM.
M1716	Gemcitabine Hydrochloride	Gemcitabine (Gemzar, LY188011) inhibits DNA synthesis with an IC50 of 0.06 µM.
M5680	Gemcitabine	Gemcitabine (LY-188011; NSC 613327) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis.
M5277	B02	B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM).
M7515	Brivudine	Brivudine is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication.
M53354	Polynucleotide kinase	Polynucleotide Kinase is a DNA repair enzyme.
M53353	Tetrapeptide	Tetrapeptide, an analogue of α-MSH, induces melanin synthesis.
M50222	Branaplam hydrochloride	Branaplam hydrochloride is an orally active, brain-permeable, selective modulator of SMN2 splicing, with an EC50 of 20 nM for SMN, and enhances full-length SMN protein and prolongs survival in a mouse model of severe spinal muscular atrophy (SMA). Branaplam hydrochloride also inhibits hERG with an IC50 of 6.3 μM.
M49842	Werner syndrome RecQ helicase-IN-3	Werner syndrome RecQ helicase-IN-3 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC50 value of 0.06 µM. Werner syndrome RecQ helicase-IN-3 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-3 shows anticancer activity.
M49841	Werner syndrome RecQ helicase-IN-4	Werner syndrome RecQ helicase-IN-4 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC50 value of 0.06 µM. Werner syndrome RecQ helicase-IN-4 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-4 shows anticancer activity.
M49840	Werner syndrome RecQ helicase-IN-2	Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research.
M44721	3-Hydroxy-2-methylpyridine	3-Hydroxy-2-methylpyridine, isolated from alkaline extracts of cocoa, is used in the synthesis of pyrimidine.
M43833	DMT-dT-CE	DMT-dT-CE is typically used in the synthesis of DNA.
M43832	DMT-dC(Ac)-CE	DMT-dC(Ac)-CE is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.
M43831	DMT-dC(Bz)-CE	DMT-dC(Bz)-CE is typically used in the synthesis of DNA.
M43830	DMT-dG(dmf)-CE	DMT-dG(dmf)-CE is a phosphinamide monomer that can be used in the preparation of oligonucleotides.
M43829	DMT-dG(iBu)-CE	DMT-dG(iBu)-CE is typically used in the synthesis of DNA.
M43828	DMT-dA(Bz)-CE	DMT-dA(Bz)-CE is typically used in the synthesis of DNA.
M42913	WRN inhibitor 4	WRN inhibitor 4, a cyclic vinyl sulfone compound, is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor.
M41479	DIZ-3	DIZ-3 is a selective multimeric G4 ligand based on a G4-ligand-dimerizing strategy.
M41478	MTR-106	MTR-106 is a potent and orally active G-quadruplex stabilizer and RNA polymerase I inhibitor.
M41473	qsl-304	qsl-304 is a DNA gyrase B inhibitor.
M41472	DNA Gyrase-IN-7	DNA Gyrase-IN-7 is a novel Microbial DNA-Gyrase inhibitor.
M41471	RNase L-IN-1	RNase L-IN-1 is an inhibitor of RNase L, or Ribonuclease L.
M41470	Votoplam	Votoplam is a gene splicing modulator, used to inhibit Huntington's disease.

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